DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycC and CCNT2

DIOPT Version :9

Sequence 1:	NP_476848.1	Gene:	CycC / 41801	FlyBaseID:	FBgn0004597	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_490595.1	Gene:	CCNT2 / 905	HGNCID:	1600	Length:	730	Species:	Homo sapiens

Alignment Length:	244	Identity:	61/244 - (25%)
Similarity:	110/244 - (45%)	Gaps:	37/244 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCILLASKVEEFG-----VIS 104
            ||:||.:|::|.:.|..|.||.||..|||..:|....:..:::.|.:.||:||||..     ||
Human    41 ANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVI- 104

  Fly   105 NSRLISIC----QSAIKTKFSYAYAQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQD 165
              ::...|    :..:.||.. ||.|:    |..::..|..:|:.|...:.:..|:..:::..|.
Human   105 --KVAHACLHPLEPLLDTKCD-AYLQQ----TQELVILETIMLQTLGFEITIEHPHTDVVKCTQL 162

  Fly   166 MGQEDQLLTLSWRIVNDSLR-TDVCLLYPPYQIAIACLQIAC------VILQKDATKQW-FAELN 222
            :.....|...|:.:..:||. |..||.|.|..||..|:.:||      :.:..|....| :.:..
Human   163 VRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPT 227

  Fly   223 VDLDKVQEIVRAIVNLYELW-------KDWK-----EKDEIQMLLSKIP 259
            |.|:.:.|:....:.:.|..       ::|:     .|.::...:|:.|
Human   228 VTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycC	NP_476848.1	CYCLIN_CCNC_rpt1	40..146	CDD:410217	34/109 (31%)
CycC	NP_476848.1	CYCLIN_CCNC_rpt2	154..245	CDD:410218	22/105 (21%)
CCNT2	NP_490595.1	Interaction with MDFIC and MDFI. /evidence=ECO:0000269\|PubMed:17289077	1..300		61/244 (25%)
		CCL1	8..>216	CDD:227640	51/182 (28%)
		CYCLIN	37..108	CDD:238003	25/69 (36%)
		Interaction with POLR2A. /evidence=ECO:0000269\|PubMed:15563843	250..300		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..430
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810