DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycC and CCNT1

DIOPT Version :9

Sequence 1:	NP_476848.1	Gene:	CycC / 41801	FlyBaseID:	FBgn0004597	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001231.2	Gene:	CCNT1 / 904	HGNCID:	1599	Length:	726	Species:	Homo sapiens

Alignment Length:	289	Identity:	67/289 - (23%)
Similarity:	116/289 - (40%)	Gaps:	58/289 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSSHSQQWILDKPDLLRERQHDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKR 71
            ::|.|:::.:|....|..||.                .||::|.:|::|.:.|..|.||.||..|
Human    20 ENSPSRRFGVDPDKELSYRQQ----------------AANLLQDMGQRLNVSQLTINTAIVYMHR 68

  Fly    72 FYARNSLKNIDPLLLAPTCILLASKVEE-----FGVISNSRLISICQSAIKTKFSYAYAQEFPYR 131
            ||...|........:||..:.||:||||     ..||..:......|.::....|.||.|:
Human    69 FYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQ---- 129

  Fly   132 TNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLR-TDVCLLYPPY 195
            ...::..|..:|:.|...|.:..|:..:::..|.:.....|...|:.:..:||. |...|.|.|.
Human   130 VQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPP 194

  Fly   196 QIAIACLQIAC------VILQKDATKQW-FAELNVDLDKVQEIVRAIVNLYE--------LWKDW 245
            .:|..|:.:||      :.:..|....| :.:..|.|:.:.|:....:.:.|        :| :|
Human   195 VVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIW-NW 258

  Fly   246 K----------------EKDEIQMLLSKI 258
            :                ||...|.:|:.|
Human   259 RACEAAKKTKADDRGTDEKTSEQTILNMI 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycC	NP_476848.1	CYCLIN_CCNC_rpt1	40..146	CDD:410217	32/110 (29%)
CycC	NP_476848.1	CYCLIN_CCNC_rpt2	154..245	CDD:410218	21/106 (20%)
CCNT1	NP_001231.2	Cyclin_N	13..149	CDD:278560	39/148 (26%)
		Nuclear localization signal, and interaction with Tat-TAR RNA. /evidence=ECO:0000255	253..270		2/17 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810