DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycC and CCNK

DIOPT Version :9

Sequence 1:	NP_476848.1	Gene:	CycC / 41801	FlyBaseID:	FBgn0004597	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001092872.1	Gene:	CCNK / 8812	HGNCID:	1596	Length:	580	Species:	Homo sapiens

Alignment Length:	284	Identity:	80/284 - (28%)
Similarity:	120/284 - (42%)	Gaps:	54/284 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WILDKPDLLR--ERQHDLLALNEDEYQKV---FIFFANVIQVLGEQLKLRQQVIATATVYFKRFY 73
            |..||.||..  .:...|....|..|::.   |||      .:|.:|.|....:||..:||.|||
Human    24 WYWDKKDLAHTPSQLEGLDPATEARYRREGARFIF------DVGTRLGLHYDTLATGIIYFHRFY 82

  Fly    74 ARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSAIKTKFSYAYAQEF------PYRT 132
            ..:|.|.....:....|:.||.||||        ....|:..|||..|.....:|      |  .
Human    83 MFHSFKQFPRYVTGACCLFLAGKVEE--------TPKKCKDIIKTARSLLNDVQFGQFGDDP--K 137

  Fly   133 NHILECEFYLLENLDCCLIVYQPYRPLL----QLVQDMGQEDQLLTLSWRIVNDSLRTDVCLLYP 193
            ..::..|..||:.:...|.|..||:.||    ||..|..:..:|:.::|..|||||.|.:.|.:.
Human   138 EEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWE 202

  Fly   194 PYQIAIACLQIA---CVI-----LQKDATKQWFAEL--NVDLDKVQEIVRAIVNLYELWKDWKEK 248
            |..||:|.:.:|   |..     ..|...::|:.:.  :|.:|.:::|...|::||...|.
Human   203 PEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQ---- 263

  Fly   249 DEIQM------LLSKIPKPKPPPQ 266
               ||      .|.:.|..:|.||
Human   264 ---QMPHHTPHQLQQPPSLQPTPQ 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycC	NP_476848.1	CYCLIN_CCNC_rpt1	40..146	CDD:410217	32/114 (28%)
CycC	NP_476848.1	CYCLIN_CCNC_rpt2	154..245	CDD:410218	31/104 (30%)
CCNK	NP_001092872.1	CYCLIN_CCNK_rpt1	40..154	CDD:410233	35/129 (27%)
		CYCLIN_CCNK_rpt2	158..258	CDD:410234	28/99 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..580		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810