DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycC and Ccnh

DIOPT Version :9

Sequence 1:	NP_476848.1	Gene:	CycC / 41801	FlyBaseID:	FBgn0004597	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_075732.1	Gene:	Ccnh / 66671	MGIID:	1913921	Length:	323	Species:	Mus musculus

Alignment Length:	249	Identity:	69/249 - (27%)
Similarity:	120/249 - (48%)	Gaps:	35/249 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAPTCI 91
            |:.|.|.: .|:|..:.|.:|.:.     .:.:.|:.||.:||||||..||:....|.::..||.
Mouse    51 HEELTLCK-YYEKRLLEFCSVFKP-----AMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCA 109

  Fly    92 LLASKVEEFGVISNSRLISICQSAIKTKFSYAYAQEFPYRTNHILECEFYLLENLDCCLIVYQPY 156
            .||.||:||.|.|...:.::.:|.:        .||  .....|||.|..|::.|:..|||:.||
Mouse   110 FLACKVDEFNVSSPQFVGNLRESPL--------GQE--RALEQILEYELLLIQQLNFHLIVHNPY 164

  Fly   157 RPLLQLVQD------MGQEDQLLTLSWRIVNDSLR----TDVCLLYPPYQIAIACL----QIACV 207
            ||....:.|      |.:..::|.   :..:|.|.    ||..|||.|.|||:..:    ..|.:
Mouse   165 RPFEGFLIDIKTRYPMLENPEILR---KTADDFLSRIALTDAYLLYTPSQIALTAILSSASRAGI 226

  Fly   208 ILQKDATKQWFAELN-VDLDKVQEIVRAIVNLYELWKDWKEKDEIQMLLSKIPK 260
            .::...::....:.| ..|.::.:|::::.||.:.::. ...||:.:|..|:.:
Mouse   227 TMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEP-PRSDEVAVLKQKLER 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycC	NP_476848.1	CYCLIN_CCNC_rpt1	40..146	CDD:410217	32/105 (30%)
CycC	NP_476848.1	CYCLIN_CCNC_rpt2	154..245	CDD:410218	24/105 (23%)
Ccnh	NP_075732.1	ccl1	2..308	CDD:129660	69/249 (28%)
		CYCLIN	62..152	CDD:214641	33/104 (32%)
		Cyclin_C_2	162..262	CDD:293504	24/102 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810