DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycC and srb11

DIOPT Version :9

Sequence 1:	NP_476848.1	Gene:	CycC / 41801	FlyBaseID:	FBgn0004597	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_595953.1	Gene:	srb11 / 2539651	PomBaseID:	SPBC12D12.06	Length:	228	Species:	Schizosaccharomyces pombe

Alignment Length:	245	Identity:	83/245 - (33%)
Similarity:	117/245 - (47%)	Gaps:	29/245 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGNFWQSSHSQQWILDKPDLLRERQHDLLALNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATA 65
            ||.|:|.||...|..|..         ||.:|......|..|:...|:|..|::|:|||:|:|||
pombe     1 MAANYWASSQLTQLFLST---------DLESLEPTCLSKDTIYQWKVVQTFGDRLRLRQRVLATA 56

  Fly    66 TVYFKRF-YARNSLKNIDPLLLAPTCILLASKVEEFGVISNSRLISICQSA-----IKTKFSYAY 124
            .|..:|: ..:|..|......|..|||.|:.||||..|    .:.:||..|     :|.|.|
pombe    57 IVLLRRYMLKKNEEKGFSLEALVATCIYLSCKVEECPV----HIRTICNEANDLWSLKVKLS--- 114

  Fly   125 AQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLQLVQDMGQEDQLLTLSWRIVNDSLRTDVC 189
                  |:| |.|.||.::..||..|||:.||..|.|...|.....:.|..:|.|||||..:.:|
pombe   115 ------RSN-ISEIEFEIISVLDAFLIVHHPYTSLEQAFHDGIINQKQLEFAWSIVNDSYASSLC 172

  Fly   190 LLYPPYQIAIACLQIACVILQKDATKQWFAELNVDLDKVQEIVRAIVNLY 239
            |:..|:|:|.|.|.|:|...:....|......:.|..||...|:.|:::|
pombe   173 LMAHPHQLAYAALLISCCNDENTIPKLLDLIKSTDAFKVILCVQRIISIY 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycC	NP_476848.1	CYCLIN_CCNC_rpt1	40..146	CDD:410217	38/111 (34%)
CycC	NP_476848.1	CYCLIN_CCNC_rpt2	154..245	CDD:410218	28/86 (33%)
srb11	NP_595953.1	CCL1	1..228	CDD:227640	83/245 (34%)
		CYCLIN	32..125	CDD:238003	38/106 (36%)
		CYCLIN	137..>189	CDD:294043	20/51 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I3426
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I1627
OMA	1	1.010	-	-		QHG55499
OrthoFinder	1	1.000	-	-		FOG0003755
OrthoInspector	1	1.000	-	-		oto102050
orthoMCL	1	0.900	-	-		OOG6_103590
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1389
SonicParanoid	1	1.000	-	-		X2616
TreeFam	1	0.960	-	-
	13	12.860