DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UQCR-C1 and Pmpcb

DIOPT Version :9

Sequence 1:	NP_650401.1	Gene:	UQCR-C1 / 41800	FlyBaseID:	FBgn0038271	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_082707.1	Gene:	Pmpcb / 73078	MGIID:	1920328	Length:	489	Species:	Mus musculus

Alignment Length:	454	Identity:	317/454 - (69%)
Similarity:	363/454 - (79%)	Gaps:	14/454 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RYKSAATLQKTLLNIPATQVTKLDNGLRVASEDSGASTATVGLWIDAGSRSENEKNNGVAHFLEH 88
            |.:|.....:.:||:|.||||.|:||||||||:||.||.|||||||||||.|||||||.||||||
Mouse    41 RLRSTQAAPQVVLNVPETQVTCLENGLRVASENSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEH 105

  Fly    89 MAFKGTAKRSQTDLELEVENLGAHLNAYTSREQTVFYAKCLSKDVPKAVEILADIIQNSKLGEAE 153
            ||||||.||||.|||||:||:||||||||||||||:|||..|:|:|:||||||||||||.|||||
Mouse   106 MAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSRDLPRAVEILADIIQNSTLGEAE 170

  Fly   154 IARERSVILREMQEVESNLQEVVFDHLHATAYQGTPLGQTILGPTKNIQSIGKADLTDYIQTHYK 218
            |.|||.||||||||||:||||||||:|||||||.|.||:||||||:||:||.:.||.|||.||||
Mouse   171 IERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYITTHYK 235

  Fly   219 ASRIVLAAAGGVKHDDLVKLA--------CSSLGGLEASVLPAEVTPCRFTGSEVRVRDDSLPLA 275
            ..||||||||||.|::|::||        ||..|.:.|  ||    ||:|||||:|||||.:|||
Mouse   236 GPRIVLAAAGGVCHNELLELAKFHFGDSLCSHKGAIPA--LP----PCKFTGSEIRVRDDKMPLA 294

  Fly   276 HVAIAVEGCGWTDQDNIPLMVANTLVGAWDRSQGGGANNASNLARASAEDNLCHSFQSFNTCYKD 340
            |:|||||..||...|.|.|||||||:|.||||.|||.|.:|.||:.:...|||||||||||.|.|
Mouse   295 HLAIAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTD 359

  Fly   341 TGLWGIYFVCDPLQCEDMLFNVQTEWMRLCTMVTEAEVERAKNLLKTNMLLQLDGTTPICEDIGR 405
            |||||:|.||:.....|||..||.||.||||.|||:||.||||||||||||||||:|||||||||
Mouse   360 TGLWGLYMVCEQATVADMLHVVQNEWKRLCTDVTESEVARAKNLLKTNMLLQLDGSTPICEDIGR 424

  Fly   406 QILCYNRRIPLHELEQRIDAVSVGNVRDVAMKYIYDRCPAVAAVGPVENLPDYNRIRSSMYWLR 469
            |:||||||||:.|||.|||||....||.|..|||:|:.||:||:||:|.|||:|:|.|:|.|:|
Mouse   425 QMLCYNRRIPIPELEARIDAVDAETVRRVCTKYIHDKSPAIAALGPIERLPDFNQICSNMRWIR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UQCR-C1	NP_650401.1	PqqL	35..459	CDD:223685	309/431 (72%)
Pmpcb	NP_082707.1	PqqL	46..478	CDD:223685	309/437 (71%)
		Peptidase_M16	68..215	CDD:279066	123/146 (84%)
		Peptidase_M16_C	220..404	CDD:282978	116/189 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835694
Domainoid	1	1.000	249	1.000	Domainoid score	I2126
eggNOG	1	0.900	-	-		E1_COG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3160
Inparanoid	1	1.050	627	1.000	Inparanoid score	I856
Isobase	1	0.950	-	0	Normalized mean entropy	S617
OMA	1	1.010	-	-		QHG53495
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001232
OrthoInspector	1	1.000	-	-		oto93931
orthoMCL	1	0.900	-	-		OOG6_100777
Panther	1	1.100	-	-	LDO	PTHR11851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R743
SonicParanoid	1	1.000	-	-		X964
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740