DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UQCR-C1 and pmpcb

DIOPT Version :9

Sequence 1:	NP_650401.1	Gene:	UQCR-C1 / 41800	FlyBaseID:	FBgn0038271	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001012514.1	Gene:	pmpcb / 503532	ZFINID:	ZDB-GENE-050220-10	Length:	470	Species:	Danio rerio

Alignment Length:	447	Identity:	313/447 - (70%)
Similarity:	362/447 - (80%)	Gaps:	0/447 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MIKRYKSAATLQKTLLNIPATQVTKLDNGLRVASEDSGASTATVGLWIDAGSRSENEKNNGVAHF 85
            :|.|..||..:.:.:||:|.|::|.|||||||||||||.||.|||||||||||.|||.|||.|||
Zfish    24 VINRSVSAPAVNQVVLNVPETKLTTLDNGLRVASEDSGLSTCTVGLWIDAGSRYENEHNNGTAHF 88

  Fly    86 LEHMAFKGTAKRSQTDLELEVENLGAHLNAYTSREQTVFYAKCLSKDVPKAVEILADIIQNSKLG 150
            |||||||||.||||.|||||:||:||||||||||||||:|||..|||:|:||||||||||||.||
Zfish    89 LEHMAFKGTRKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLG 153

  Fly   151 EAEIARERSVILREMQEVESNLQEVVFDHLHATAYQGTPLGQTILGPTKNIQSIGKADLTDYIQT 215
            ||||.|||.||||||||||:||||||||:|||||||.||||:||||||:||::|.:.||.:||.|
Zfish   154 EAEIERERGVILREMQEVETNLQEVVFDYLHATAYQETPLGRTILGPTENIKTINRGDLVEYITT 218

  Fly   216 HYKASRIVLAAAGGVKHDDLVKLACSSLGGLEASVLPAEVTPCRFTGSEVRVRDDSLPLAHVAIA 280
            |||..||||||||||.|:.|:.||....|.|.|......:.||.|||||:|||||.:||||:|:|
Zfish   219 HYKGPRIVLAAAGGVSHNQLIDLAKYHFGKLPARYSGEALLPCHFTGSEIRVRDDKMPLAHIAVA 283

  Fly   281 VEGCGWTDQDNIPLMVANTLVGAWDRSQGGGANNASNLARASAEDNLCHSFQSFNTCYKDTGLWG 345
            ||..||:..|.|||||||||:|.||||.|||.|.:|.||:.|.:.|||||||||||||.||||||
Zfish   284 VEAVGWSHPDTIPLMVANTLIGNWDRSLGGGMNLSSKLAQMSCQGNLCHSFQSFNTCYTDTGLWG 348

  Fly   346 IYFVCDPLQCEDMLFNVQTEWMRLCTMVTEAEVERAKNLLKTNMLLQLDGTTPICEDIGRQILCY 410
            :|.||:|....||:...|.||..|||.|||:||.||||||||||||.|||:||||||||||:|||
Zfish   349 LYMVCEPGTVHDMIRFTQLEWKSLCTSVTESEVNRAKNLLKTNMLLHLDGSTPICEDIGRQMLCY 413

  Fly   411 NRRIPLHELEQRIDAVSVGNVRDVAMKYIYDRCPAVAAVGPVENLPDYNRIRSSMYW 467
            :|||||||||.||||::...::||.:||||::.||:|||||:|.|.|||.||:.|.|
Zfish   414 SRRIPLHELEARIDAINATTIKDVCLKYIYNKAPAIAAVGPIEQLLDYNSIRNGMCW 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UQCR-C1	NP_650401.1	PqqL	35..459	CDD:223685	303/423 (72%)
pmpcb	NP_001012514.1	PqqL	33..462	CDD:223685	303/428 (71%)
		Peptidase_M16	54..201	CDD:279066	125/146 (86%)
		Peptidase_M16_C	206..388	CDD:282978	111/181 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579021
Domainoid	1	1.000	252	1.000	Domainoid score	I2054
eggNOG	1	0.900	-	-		E1_COG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3160
Inparanoid	1	1.050	643	1.000	Inparanoid score	I792
OMA	1	1.010	-	-		QHG53495
OrthoDB	1	1.010	-	-		D287307at33208
OrthoFinder	1	1.000	-	-		FOG0001232
OrthoInspector	1	1.000	-	-		oto40260
orthoMCL	1	0.900	-	-		OOG6_100777
Panther	1	1.100	-	-	LDO	PTHR11851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R743
SonicParanoid	1	1.000	-	-		X964
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800