DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment UQCR-C1 and pmpca

DIOPT Version :9

Sequence 1:	NP_650401.1	Gene:	UQCR-C1 / 41800	FlyBaseID:	FBgn0038271	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001007443.1	Gene:	pmpca / 492801	ZFINID:	ZDB-GENE-030131-5809	Length:	517	Species:	Danio rerio

Alignment Length:	503	Identity:	143/503 - (28%)
Similarity:	261/503 - (51%)	Gaps:	57/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MRSFMR----GVDMIKRYKSAATLQKTLLNIP------------------ATQVTKLDNGLRVAS 54
            :|.:.|    |:.:.::|.|.::.....|:.|                  .|::|.|:|||::||
Zfish     8 LRGWSRAQRYGIAVCRQYSSGSSYPNVSLSTPLPGIPKPVFASVDGHEKYETKITTLENGLKIAS 72

  Fly    55 EDSGASTATVGLWIDAGSRSENEKNNGVAHFLEHMAFKGTAK-RSQTDLELEVENLGAHLNAYTS 118
            ::......|||:.:::|||.|.:..:|:|||||.::|..||: .|:.::.|.:|..|...:..||
Zfish    73 QNKFGQFCTVGILVNSGSRHEAKYPSGIAHFLEKLSFSSTAQFGSKGEILLTLEKHGGICDCQTS 137

  Fly   119 REQTVFYAKCLSKDVPKAVEILADIIQNSKLGEAEIARERSVILREMQE--VESNLQEVVFDHLH 181
            |:.|::......|.:...|.:|:|.:...:|.:.||...|..:..|:::  :..:.:.::.:.:|
Zfish   138 RDTTMYAVSAEVKGLDTVVHLLSDAVLQPRLLDEEIEMARMAVRFELEDLNMRPDPEPLLTEMIH 202

  Fly   182 ATAYQGTPLGQTILGPTKNIQSIGKADLTDYIQTHYKASRIVLAAAGGVKHDDLVKLACSSLGGL 246
            |.||:|..:|.....|..|::.|.|..|..|:|::|...|:|||.. |::|:.||:.|...|..:
Zfish   203 AAAYRGNTVGLPRFSPADNVEKIDKKLLHKYLQSYYCPERMVLAGV-GIEHEQLVQCARKYLLNV 266

  Fly   247 E---ASVLPAEV--TPCRFTGSEVR-VRDDS--------LP-LAHVAIAVEGCGWTDQDNIPLMV 296
            :   ....||.|  :..::||..|: |:|.|        :| |.|:.|.:|.|.:.::|.||..|
Zfish   267 QPVWGESKPANVDRSVAQYTGGIVKMVKDMSDVSLGPTPIPELTHIMIGLESCSFLEEDFIPFAV 331

  Fly   297 ANTLVGAWDRSQGGGANNASNLARAS---------AEDNLCHSFQSFNTCYKDTGLWGIYFVCDP 352
            .|.::|      |||:.:|....:..         ...:..::..|::..|:|:||..|:...||
Zfish   332 LNMMMG------GGGSFSAGGPGKGMFTRLYLNVLNRHHWMYNATSYHHSYEDSGLLCIHASADP 390

  Fly   353 LQCEDMLFNVQTEWMRLCTMVTEAEVERAKNLLKTNMLLQLDGTTPICEDIGRQILCYNRRIPLH 417
            .|..:|:..:..|::::.....|.|:||||..||:.:::.|:....|.||:|||:|...:|...|
Zfish   391 RQVREMVEIITREFIQMTGTAGEMELERAKTQLKSMLMMNLESRPVIFEDVGRQVLATGKRKLPH 455

  Fly   418 ELEQRIDAVSVGNVRDVAMKYIYDRCPAVAAVGPVENLPDYNRIRSSM 465
            ||.:.|..|:..:::.|.||.:..: |||||:|.:..||.|..|::::
Zfish   456 ELCELISTVTASDIKRVTMKMLRSK-PAVAALGDLTELPSYEDIQAAL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UQCR-C1	NP_650401.1	PqqL	35..459	CDD:223685	136/468 (29%)
pmpca	NP_001007443.1	PqqL	59..496	CDD:223685	134/444 (30%)
		Peptidase_M16	69..218	CDD:279066	41/148 (28%)
		Peptidase_M16_C	224..423	CDD:282978	58/205 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910