Protein Alignment Rrp6 and RRP6

DIOPT Version :9

• Sequence 1: NP_001097795.1
• Gene: Rrp6 / 41798
• FlyBaseID: FBgn0038269
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: NP_014643.1
• Gene: RRP6 / 854162
• SGDID: S000005527
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 867
• Identity: 230/867 - (26%)
• Similarity: 389/867 - (44%)
• Gaps: 196/867 - (22%)

  Fly    27 ASEDVEAFTN--KGFKNAIAATKAANAFPQGTARALYLSYPGYARVMEDLTQRVVALIGNVLHSK 89
            ||:||:.:.|  :||...:.:.                     |..:.|:...::..|.
Yeast    24 ASQDVDFYKNLDRGFSKDLKSK---------------------ADKLADMANEIILSID------ 61

  Fly    90 DIKGDIKKRQPEEQFEMVQECNDVLFERITTNLDIKGGLRRNTQQVVEAQVDVMSSSTSIEPAVA 154
                     :..|.||:.:|....|:...       |.:..|..::.:..:|.::.:.:.:...:
Yeast    62 ---------EHHESFELKEEDISDLWNNF-------GNIMDNLLEMSDHSLDKLNCAINSKSRGS 110

  Fly   155 SPQTQGTPKAGSWNRTTGTPQRSMVSARLFTAKNIVRPQTQFREPVDNSAQNPFVPRLKEKPNSL 219
            ..|..|.....:::.|                |.:.:||.:|:.|:|||..:||:|.||||||:|
Yeast   111 DLQYLGEFSGKNFSPT----------------KRVEKPQLKFKSPIDNSESHPFIPLLKEKPNAL 159

  Fly   220 KPL--ALLPEYDDAGNVQSYLHPYEFEL--LKFQPPEEQFQKQKPVLPALMAETELMV-VDTVEK 279
            |||  :|....||..|...|.||||:|:  .::.|...|.:::   :|:...:..:.: |||..:
Yeast   160 KPLSESLRLVDDDENNPSHYPHPYEYEIDHQEYSPEILQIREE---IPSKSWDDSVPIWVDTSTE 221

  Fly   280 LKQALEELRQAPQIAIDVEHHSYRTFMGITCLVQMSTRSKDYIFDTLILRDDMHILNLVLTDPKK 344
            |:..||:|:...:||:|:|||.||::.||.||:|:|||.:||:.|||.||:::||||.|.|:|..
Yeast   222 LESMLEDLKNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNEVFTNPSI 286

  Fly   345 LKILHGADLDIEWLQRDLSLYIVNMFDTHRAAKALNMARLSLAYLLKHYLDLDVDKSLQLADWRM 409
            :|:.|||.:||.||||||.||:|.:|||:.|:||:.:.|.||||||:::.:....|..||||||:
Yeast   287 VKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLAYLLENFANFKTSKKYQLADWRI 351

  Fly   410 RPLPQQLVDYARQDTHFLIYVYGRMTNDLLQQHAEPGLLGSVYQQSTDVCKKRYNKPHIGP---- 470
            |||.:.:..|||.|||||:.:|.::.|.|:    |...|..|..:|.:|.|:|:......|
Yeast   352 RPLSKPMTAYARADTHFLLNIYDQLRNKLI----ESNKLAGVLYESRNVAKRRFEYSKYRPLTPS 412

  Fly   471 ---------ESHLDLVRKTKRSFDNRQLYALRGIFEWRDATARSEDESYGYVLPNHMMLQIAESL 526
                     ||...::.........|:: .:|.:::|||..||.:|||..:|:||.::..:....
Yeast   413 SEVYSPIEKESPWKILMYQYNIPPEREV-LVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYT 476

  Fly   527 PREMQGILACCNPIPPLVRQQLHTLHQIVLKARDQPLVKPILEAHSSTQAALPPSTKDFSSKLYC 591
            |.::.|:::..|.:...|||....|..:
Yeast   477 PTDVIGVVSLTNGVTEHVRQNAKLLANL------------------------------------- 504

  Fly   592 PHDFSQLEEIRDDLPTLLKRNSTTGKLEVPNKEEVAKVD----PTLAAPAMALFEKQSKPTQEEE 652
                     |||.|..:  :|:......:|:.|  .|.|    .|::.|.:          ::..
Yeast   505 ---------IRDALRNI--KNTNEEATPIPSSE--TKADGILLETISVPQI----------RDVM 546

  Fly   653 QRWAHLRKE--SQTMRMPYKRYLAILPLMVQLKADQLARERSELQKRQLCPAAPTVEQNIKLEAH 715
            :|::.|...  |::...|......:|..::..:...:|..:..|..:..........||.|   .
Yeast   547 ERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKDGLPNKVKTEDIRIRAQNFK---S 608

  Fly   716 AIGKEDDDMYS------VPLK-EQLKRKHPQANVKTDPEQQPTASKRPRKDENSQTKPPVKIEPV 773
            |:...:|.::.      ||:| |::|...|.:.....||..........|.:|.|.|.|.|.:.|
Yeast   609 ALANLEDIIFEIEKPLVVPVKLEEIKTVDPASAPNHSPEIDNLDDLVVLKKKNIQKKQPAKEKGV 673

  Fly   774 EKVQQALGESDDEVVEVPIERQATEPPK-PS-----PAQNNRKQKKNQFQRGFKAKNRGNHPQSS 832
                              .|:.|.:..| |:     |.||||:|||.:|.   .:.:..|.|:::
Yeast   674 ------------------TEKDAVDYSKIPNILSNKPGQNNRQQKKRRFD---PSSSDSNGPRAA 717

  Fly   833 SQQVPQHKGTGNFDYKNVDFRQ 854
            .::.|..||      ||:.|::
Yeast   718 KKRRPAAKG------KNLSFKR 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	8/69 (12%)
		Rrp6p_like_exo	268..456	CDD:99850	89/188 (47%)
		rnd	273..622	CDD:130455	121/362 (33%)
		HRDC	485..565	CDD:128635	20/79 (25%)
		MSA_2	735..>833	CDD:144541	25/103 (24%)
RRP6	NP_014643.1	PMC2NT	16..100	CDD:285328	18/118 (15%)
		Rrp6p_like_exo	209..399	CDD:99850	91/193 (47%)
		Rnd	216..622	CDD:223426	139/473 (29%)
		HRDC	435..515	CDD:128635	24/128 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344862
Domainoid	1	1.000	190	1.000	Domainoid score	I636
eggNOG	1	0.900	-	-		E1_COG0349
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	318	1.000	Inparanoid score	I457
Isobase	1	0.950	-	0	Normalized mean entropy	S2387
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003372
OrthoInspector	1	1.000	-	-		oto98987
orthoMCL	1	0.900	-	-		OOG6_101473
Panther	1	1.100	-	-	LDO	PTHR12124
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1224
SonicParanoid	1	1.000	-	-		X2726
TreeFam	1	0.960	-	-
	14	13.730