DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rrp6 and AT5G35910

DIOPT Version :9

Sequence 1:	NP_001097795.1	Gene:	Rrp6 / 41798	FlyBaseID:	FBgn0038269	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_198440.2	Gene:	AT5G35910 / 833577	AraportID:	AT5G35910	Length:	870	Species:	Arabidopsis thaliana

Alignment Length:	976	Identity:	259/976 - (26%)
Similarity:	423/976 - (43%)	Gaps:	216/976 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DQPPKKSASEDVEAFTN-KGFKNAIA-ATKAANAFPQGTARALYLSYPGYARVMEDLT---QRVV 79
            |:.|.....:.:|...: ..|.:.:: .:.::...|.......|.::..:.|.::::|   |..:
plant     9 DESPVSWKVKSLEKLIDGSSFSSTLSRLSSSSRLIPTSRDFHFYYNFDEFKRPIDEITGTSQSTL 73

  Fly    80 ALIGN--VLHSKDIK--GDIKKRQPEEQFEMVQECNDVLFERITTNLDIKGGLRRNTQQVVEAQV 140
            |.||:  .:..|.:|  ||:.....|   :.:...||.|.||...::|       ..|::.:.:.
plant    74 ATIGDSEQVWGKSMKFPGDVDDVYAE---DWLCNVNDELIERFDVSVD-------EFQRIRKKEK 128

  Fly   141 DVMSSSTSIEPAVASPQTQGTPKAGSWNRTTGTPQRSMVSARLFTAKNIVRPQTQFREPVDNS-- 203
            ::..|..:.:.........|..|....|..||       ||.:....:::  ..:..|...||
plant   129 EIGRSVVADDGDDGFQMVYGKKKKPVGNVVTG-------SAAVNGGGSVI--DVKMAERDKNSSG 184

  Fly   204 -AQNPF-VPRLK---EKPNSLKPLALLP--------EYDDAGNVQSYLHPYE-FELLKFQPPEEQ 254
             |:.|| ||.:|   |:.|.|...|.||        ..||.    ..:||.| |.:|.|  .::.
plant   185 KAKVPFHVPTIKKPQEEYNILVNNANLPFEHVWLERSEDDL----RAMHPLEKFSVLDF--VDKD 243

  Fly   255 FQKQKPVLPALMAETELMVVDTVEKLKQALEELRQAPQIAIDVEHHSYRTFMGITCLVQMSTRSK 319
            ..:.:||.|..:.:|....|..|:.||:.:.:||...:.|:|:||:.||:|.|:|||:|:|||::
plant   244 VNEMEPVKPLPLEQTPFKFVQEVKDLKELVAKLRSVEEFAVDLEHNQYRSFQGLTCLMQISTRTE 308

  Fly   320 DYIFDTLILRDDMHI---LNLVLTDPKKLKILHGADLDIEWLQRDLSLYIVNMFDTHRAAKALNM 381
            |||.||..||  :||   |..:..||||.|::||||.||.|||||..:|:.|:|||.:|::.||:
plant   309 DYIVDTFKLR--IHIGPYLREIFKDPKKKKVMHGADRDIIWLQRDFGIYVCNLFDTGQASRVLNL 371

  Fly   382 ARLSLAYLLKHYLDLDVDKSLQLADWRMRPLPQQLVDYARQDTHFLIYVYG-------RMTNDLL 439
            .|.||.:||:|:..:..:|..|.||||:||||:::..|||:|||:|:|:|.       ||..|
plant   372 ERNSLEFLLQHFCGVTANKEYQNADWRIRPLPEEMTRYAREDTHYLLYIYDLIKLELQRMAKD-- 434

  Fly   440 QQHAEPGLLGSVYQQSTDVCKKRYNKPHIGPESHLDLVRKTKRSFDNRQLYALRGIFEWRDATAR 504
            ..|.:..|| .||::|.|||.:.|.|..:...|:|.:.......|:..||..:.|:.||||..||
plant   435 DAHTDSPLL-EVYKRSYDVCTQLYEKELLTENSYLHVYGLQAAGFNAAQLAIVAGLCEWRDFIAR 498

  Fly   505 SEDESYGYVLPNHMMLQIAESLP---REMQGILACCNP--------IPPLVRQQLH---TLHQIV 555
            :||||.||||||.::|:||:.:|   .:::.:|...:|        :..::||.:.   ......
plant   499 AEDESTGYVLPNKVLLEIAKEMPDSVGKLRRMLKSKHPYIERNVDSVVSVIRQSMQHYAAFESAA 563

  Fly   556 LKARD-------QPLVKPILE---AHSSTQAALPPSTKDFSSKLYCPHDFSQLEEIRDDLPTLLK 610
            |..:|       ...::||.|   .|:...|:  ||.|:.|         ||||..||.:.....
plant   564 LSLKDVSPGNVMDKNIEPISEKKDLHTGDVAS--PSLKENS---------SQLESTRDLIMGAAN 617

  Fly   611 RN-------STTGKLEVPNKEEVAKVDPTLAAPAMALFEKQSKPTQEEEQRWAHLRKESQTMRMP 668
            .|       ...|..:|.....::| .|:....|: |....||             |:|:|
plant   618 TNEGRGLGSGLFGSAKVSAAVRISK-KPSSGLGAL-LGNAASK-------------KKSRT---- 663

  Fly   669 YKRYLAILPLMVQLKADQLARERSELQKRQLCPAAPTVEQNIKLEAHAIGKEDDD---------- 723
                            |:..:|..:|::         :..::.|..|:..::..|
plant   664 ----------------DEKVKEDVKLEQ---------IRSSVNLSFHSFTEKVPDSKSTSETSPK 703

  Fly   724 MYSVPLKEQLKRKHPQANVKTDPEQQPTASKRPRKDENSQTKPPV---------KIEPVEKVQQA 779
            :|..|  |::....|.:..|.|       ..:..||::.:....|         |:...|.....
plant   704 VYGKP--EEMSSTMPASVSKED-------GVKELKDDSEEASEIVGTSGRVSESKVSSSEMGDII 759

  Fly   780 LGESDDEVVEVPIERQATEPPKPSPAQNNRKQKKNQFQRGFKAKNRGNHPQSSSQQVPQHKGTGN 844
            |.|:.|| .:|..|   .||...|....|       ||:.||:.|:....|..::.:    ....
plant   760 LLENGDE-KKVDAE---DEPMSLSELSTN-------FQKCFKSMNKSKKAQKQTEFL----NIEP 809

  Fly   845 FDY----KNVDFRQFKGGAQRARGTEIKQQIRGKNRPNNRNNKQF-------------NKLFTFS 892
            |||    |.|.|.:...|.|..|     :...|:.:.:.:...:|             |:..:|.
plant   810 FDYEAARKEVKFGEGHKGRQGKR-----EAAAGQKKGSTQEQSEFGQGKRRQAFPASGNRSMSFK 869

  Fly   893 N 893
            |
plant   870 N 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	18/76 (24%)
		Rrp6p_like_exo	268..456	CDD:99850	89/197 (45%)
		rnd	273..622	CDD:130455	144/389 (37%)
		HRDC	485..565	CDD:128635	29/100 (29%)
		MSA_2	735..>833	CDD:144541	24/106 (23%)
AT5G35910	NP_198440.2	PMC2NT	46..121	CDD:285328	18/84 (21%)
		Rrp6p_like_exo	256..448	CDD:99850	89/196 (45%)
		HRDC	482..549	CDD:278967	25/66 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1087
eggNOG	1	0.900	-	-		E1_COG0349
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I1039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D677201at2759
OrthoFinder	1	1.000	-	-		FOG0003372
OrthoInspector	1	1.000	-	-		otm3273
orthoMCL	1	0.900	-	-		OOG6_101473
Panther	1	1.100	-	-	LDO	PTHR12124
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2726
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830