DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rrp6 and Exosc10

DIOPT Version :9

Sequence 1:	NP_001097795.1	Gene:	Rrp6 / 41798	FlyBaseID:	FBgn0038269	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_006539086.1	Gene:	Exosc10 / 50912	MGIID:	1355322	Length:	898	Species:	Mus musculus

Alignment Length:	954	Identity:	330/954 - (34%)
Similarity:	492/954 - (51%)	Gaps:	162/954 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRTPKRVHQEAKEESA-QADQPPKKSASEDVEAFTNKGFKNAIAATKAANAFPQ-GTARALYLSY 64
            |.:| |.||.|...|| :.|.........|.::|......:.:|.|||:...|| |.....|.|:
Mouse     3 PPSP-REHQSAPATSATKPDAEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSF 66

  Fly    65 PGYARVMEDLTQRVVALIGNVLHSKDIKGDIKKR----QPEEQFEMVQECNDVLFERITTNLDIK 125
            |.:....|....|::..:..|:.....:.:||.|    :.|::|:::.:.|||:.||:...||..
Mouse    67 PAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDTNDVILERVGMLLDEA 131

  Fly   126 GGLRRNTQQVVEAQVDVMSSSTSIEPAVASPQTQGTPKAGSWNRTTGTPQRSMVSA--RLFTAKN 188
            .|:.::.|.|:.|.:.|..:..|                 ||||..|...:...|.  ||..|||
Mouse   132 SGVNKHQQPVLPAGLQVPKTIVS-----------------SWNRKAGEYGKKAKSETFRLLHAKN 179

  Fly   189 IVRPQTQFREPVDNSAQNPFVPRLKEKPNSLKPLAL----------------------LPEYDDA 231
            |||||.:|||.:||| ..||:|::..|||:.|||.|                      |.::...
Mouse   180 IVRPQLRFREKIDNS-NTPFLPKIFVKPNARKPLPLALSKERRERPQDRPEDLDVPPALADFIHQ 243

  Fly   232 GNVQS-----YLHPYEFELLKFQPPEEQFQKQKPVLPALMAETELMVVDTVEKLKQALEELRQAP 291
            ...|.     :.|||::||..|.||:...|:.||.|...:.||...:|.::::|.:..|:|....
Mouse   244 QRTQQVEQDMFAHPYQYELDHFTPPQSVLQRPKPQLYRAVGETPCHLVSSLDELVELNEKLLGCQ 308

  Fly   292 QIAIDVEHHSYRTFMGITCLVQMSTRSKDYIFDTLILRDDMHILNLVLTDPKKLKILHGADLDIE 356
            :.|:|:||||||:|:|:|||:|:|||::|:|.|||.||.||:|||..||||..:|:.||||.|||
Mouse   309 EFAVDLEHHSYRSFLGLTCLMQISTRTEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIE 373

  Fly   357 WLQRDLSLYIVNMFDTHRAAKALNMARLSLAYLLKHYLDLDVDKSLQLADWRMRPLPQQLVDYAR 421
            |||:|..||:|||||||:||:.||:||.||.:||:.|..::.:|..||||||:||||::::.|||
Mouse   374 WLQKDFGLYVVNMFDTHQAARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLSYAR 438

  Fly   422 QDTHFLIYVYGRMTNDLLQQ-HAEPGLLGSVYQQSTDVCKKRYNKPHIGPESHLDLVRKTKRSFD 485
            .|||:|:|:|.||..:|.:: :.:|..|..|:|:|.|:|.|::.||....||:|:|.||.|:..:
Mouse   439 DDTHYLLYIYDRMRLELWERGNHQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLN 503

  Fly   486 NRQLYALRGIFEWRDATARSEDESYGYVLPNHMMLQIAESLPREMQGILACCNPIPPLVRQQLHT 550
            ::||.|.:.:|.|||.|||.|||||||||||||||:|||.||:|.|||:|||||:|||||||::.
Mouse   504 SQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINE 568

  Fly   551 LHQIVLKARDQPLVKPILEAHSSTQAALP-PSTKDFSSKLYCPHDFSQLEEIRDDLPTLLKRNST 614
            :|.::.:||:.||:|.  |..:..:.:.| ||.:...:.|:.|||.|...      |...:..||
Mouse   569 MHLLIQQAREMPLLKS--ENAAGVRKSGPLPSAERLENDLFGPHDCSHAP------PDNYQNTST 625

  Fly   615 TGKLEV--------PNKEEVAKVDP--TLAAPAMALFEKQSKPTQEEEQRWAHLRKESQTMRMPY 669
            .|.|.:        ..|||.: ||.  .||...:.||   |:|..||..:
Mouse   626 DGTLPLQKQPSLFTEGKEETS-VDAGCLLATAVITLF---SEPNTEEGGK--------------- 671

  Fly   670 KRYLAILPLMVQLKADQLARERSELQKRQLCPA---APTVEQNIKLEAHAIGKEDDDMYSVPLKE 731
                  .||.|..|..|...:..|...|...|:   ...:.|..|.:..:...|..:.:.:..:.
Mouse   672 ------TPLTVAQKKAQNIMQSFENPFRMFLPSLEHKAHISQAAKFDPSSKIYEISNRWKLASQV 730

  Fly   732 QLKRKHPQANVKTDPEQQPTASKRPRKDENSQTKPPVKIEPVEKVQQALGESDDEVVEVPIERQA 796
            |::::..:|..|...||  ||::...|:|.:          ...::||          :|:.:||
Mouse   731 QVQKEPKEATKKKVAEQ--TAAREEAKEEAA----------AGVLEQA----------IPVRQQA 773

  Fly   797 ---TEPPKPSPAQNN-----RKQKKNQFQRGFKAKNRGNHPQSSSQQVPQHKGTGNFDYKNVDFR 853
               ....|...|.::     :||:|.:.:...|||:    |.      |..|....:||...|||
Mouse   774 ALENATKKRERATSDLRTIEQKQEKKRLKSSKKAKD----PD------PPGKDFSPYDYSQSDFR 828

  Fly   854 QFKGGAQRARGTEIKQQIRGKNRPNNRNNKQF--NKLFTFSNVR 895
            .|.|.:              |::|::    ||  |||.....||
Mouse   829 AFAGDS--------------KSKPSS----QFDPNKLAPSGKVR 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	19/73 (26%)
		Rrp6p_like_exo	268..456	CDD:99850	98/188 (52%)
		rnd	273..622	CDD:130455	175/358 (49%)
		HRDC	485..565	CDD:128635	51/79 (65%)
		MSA_2	735..>833	CDD:144541	22/105 (21%)
Exosc10	XP_006539086.1	PMC2NT	46..133	CDD:369677	24/86 (28%)
		Rrp6p_like_exo	285..474	CDD:99850	98/188 (52%)
		HRDC	503..583	CDD:128635	51/79 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842773
Domainoid	1	1.000	205	1.000	Domainoid score	I2939
eggNOG	1	0.900	-	-		E1_COG0349
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	472	1.000	Inparanoid score	I1491
Isobase	1	0.950	-	0	Normalized mean entropy	S2387
OMA	1	1.010	-	-		QHG47749
OrthoDB	1	1.010	-	-		D267612at33208
OrthoFinder	1	1.000	-	-		FOG0003372
OrthoInspector	1	1.000	-	-		oto92005
orthoMCL	1	0.900	-	-		OOG6_101473
Panther	1	1.100	-	-	LDO	PTHR12124
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1224
SonicParanoid	1	1.000	-	-		X2726
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750