DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rrp6 and exosc10

DIOPT Version :9

Sequence 1:	NP_001097795.1	Gene:	Rrp6 / 41798	FlyBaseID:	FBgn0038269	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_957383.2	Gene:	exosc10 / 394064	ZFINID:	ZDB-GENE-040426-781	Length:	899	Species:	Danio rerio

Alignment Length:	976	Identity:	321/976 - (32%)
Similarity:	473/976 - (48%)	Gaps:	216/976 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AKEESA----QADQPPKKSASE----------DVEAFTNKGFKNAIAATKAANAFPQ-GTARALY 61
            |...||    |:|..|....:|          ||:.|...|....::||||:.|.|. |....||
Zfish     3 ASSSSAAVAKQSDHSPSAEETEAETEFCPGFKDVDTFVKHGLGAVVSATKASAALPSAGDEFDLY 67

  Fly    62 LSYPGYARVMEDLTQRVVALIGNVLHSKDIKGDIKKRQP----EEQFEMVQECNDVLFERITTNL 122
            .|:..:.:.......|::..:..::.....:..::.|..    |::|::|.:.||.:.|::...|
Zfish    68 RSFSSFQQFCASQGDRLLHCMSQIMQHHGCRSHMRDRNKLTGLEDRFDLVVDANDAILEKVGILL 132

  Fly   123 DIKGGLRRNTQQVVEAQVDVMSSSTSIEPAVASPQTQGTPK--AGSWNRTTGTPQRSMVSARLFT 185
            |...|:.|:.|.|:              ||...|     ||  ..||||..|..:..  :.:|..
Zfish   133 DEASGVSRSQQPVM--------------PAGYQP-----PKIIVSSWNRKGGGSRAQ--TFQLLA 176

  Fly   186 AKNIVRPQTQFREPVDNSAQNPFVPRLKEKPNSLKPL--------------------ALLPEY-- 228
            ||||.|||.:||:.|||| ..||:.::..|||::|||                    |.|.::
Zfish   177 AKNIQRPQLKFRDKVDNS-NTPFLSKIFIKPNAVKPLPSYFADKHIRKERPEDLDVPAALADFIH 240

  Fly   229 --------DDAGNVQSYLHPYEFELLKFQPPEE-----QFQKQKPVLPALMAETELMVVDTVEKL 280
                    ||     .:.|||::||.....||.     :.|..||:     .||....:.|:|.|
Zfish   241 QQRTKEHVDD-----MFSHPYQYELDHLVMPENLKCKPEVQMYKPI-----DETPCQFISTLEDL 295

  Fly   281 KQALEELRQAPQIAIDVEHHSYRTFMGITCLVQMSTRSKDYIFDTLILRDDMHILNLVLTDPKKL 345
            ....|:|.:..:.|:|:||||||:|:|||||:|:|||.:|:|.|||.||.:|:|||...|||..:
Zfish   296 VALNEKLAKTTEFAVDLEHHSYRSFLGITCLMQISTREEDFIIDTLELRSEMYILNETFTDPAIV 360

  Fly   346 KILHGADLDIEWLQRDLSLYIVNMFDTHRAAKALNMARLSLAYLLKHYLDLDVDKSLQLADWRMR 410
            |:.||||.||||||:|..||:|||||||.||:.||:.|.||.:|||.|.|:..||..||||||:|
Zfish   361 KVFHGADSDIEWLQKDFGLYVVNMFDTHHAARCLNLGRNSLDHLLKVYCDVSSDKRYQLADWRIR 425

  Fly   411 PLPQQLVDYARQDTHFLIYVYGRMTNDLLQ-QHAEPGLLGSVYQQSTDVCKKRYNKPHIGPESHL 474
            |||.:::.||:.|||:|:|||.|:..||.. .:.:..|:..|:.:|.|:..|:|.||....:|::
Zfish   426 PLPDEMLKYAQADTHYLLYVYDRVRADLFDGGNGQATLIQQVWTKSRDLSLKKYVKPIFTEDSYM 490

  Fly   475 DLVRKTKRSFDNRQLYALRGIFEWRDATARSEDESYGYVLPNHMMLQIAESLPREMQGILACCNP 539
            :|.||.|:||:.:||.|.|.::.|||..||.||||.||:||||||::||:.||:|.|||:|||||
Zfish   491 ELYRKQKKSFNTQQLAAFRLMYAWRDKLAREEDESTGYILPNHMMMKIADELPKEPQGIIACCNP 555

  Fly   540 IPPLVRQQLHTLHQIVLKARDQPLVKPILEAHSSTQAALPPSTKDFSSKLYCPHDFSQLEEIRDD 604
            .|||||||::.|||::.:||:.||:|  .|..:..:.::.|..|. .|.|:.|||.|:..|  .|
Zfish   556 TPPLVRQQINELHQLIKQARETPLLK--AEVVAQKRKSMTPKRKP-QSTLFGPHDTSRSSE--SD 615

  Fly   605 LPTLLKRNSTTGKLEVPNK-------EEVAKVDPT------LAAPA-MALFEKQSKPTQEEEQRW 655
            ...|       ...|.|.|       |:...||..      |.||| ::||.:...|..
Zfish   616 FLDL-------SSFETPTKPGMLFSEEDEESVDREKKSVHGLTAPAKISLFAEDVSPAS------ 667

  Fly   656 AHLRKESQ-------TMRMPYKRYLAILPLMV--QLKADQLAR-----ERSELQKRQLCPAAPTV 706
            |||....|       :...|::.||....:.:  ..|.|..::     .|.:||         ::
Zfish   668 AHLTVAQQKSHSIMESFENPFRMYLPSKDIHISKNAKYDPSSKIYEIHNRWKLQ---------SI 723

  Fly   707 EQNIKLEAHAIGKEDDDMYSVPLKEQLKRKHPQ------------ANVKTDPEQQPTASKRPRKD 759
            ||..| ||.|  |:.       .|||.|:...:            .||.|..||...|.:..:|.
Zfish   724 EQQQK-EAQA--KQQ-------AKEQAKKAQEERKKAKQTYQESLQNVHTVREQVKEAKQAGQKR 778

  Fly   760 ENSQT-------KPPVKIEPVEKVQQALGESDDEVVEVPIERQATEPPKPSPAQNNRKQKKNQFQ 817
            |.:.:       ||.||:...|.             |..:..|:|:|.|       :|||:...|
Zfish   779 ERAASDVSEDSLKPNVKLSKSEG-------------ETTVADQSTKPAK-------KKQKQKTAQ 823

  Fly   818 RGFKAKNRGNHPQSSSQQVPQHKGTGNFDYKNVDFRQFKGGAQ-------RARGTEIKQQIRGKN 875
                      .|::..|....      :||...:|:.|.|.::       ..:|.:.|:.::|:.
Zfish   824 ----------EPEAPKQDFKP------YDYSQSNFKLFAGKSKDGSHFDPNRQGPKQKKNLKGQK 872

  Fly   876 R 876
            :
Zfish   873 K 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	14/73 (19%)
		Rrp6p_like_exo	268..456	CDD:99850	98/188 (52%)
		rnd	273..622	CDD:130455	171/349 (49%)
		HRDC	485..565	CDD:128635	48/79 (61%)
		MSA_2	735..>833	CDD:144541	23/116 (20%)
exosc10	NP_957383.2	PMC2NT	50..136	CDD:285328	20/85 (24%)
		Rrp6p_like_exo	282..472	CDD:99850	98/189 (52%)
		HRDC	501..581	CDD:128635	48/79 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587211
Domainoid	1	1.000	203	1.000	Domainoid score	I2924
eggNOG	1	0.900	-	-		E1_COG0349
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1670
OMA	1	1.010	-	-		QHG47749
OrthoDB	1	1.010	-	-		D267612at33208
OrthoFinder	1	1.000	-	-		FOG0003372
OrthoInspector	1	1.000	-	-		oto41533
orthoMCL	1	0.900	-	-		OOG6_101473
Panther	1	1.100	-	-	LDO	PTHR12124
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1224
SonicParanoid	1	1.000	-	-		X2726
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800