DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rrp6 and egl

DIOPT Version :9

Sequence 1:	NP_001097795.1	Gene:	Rrp6 / 41798	FlyBaseID:	FBgn0038269	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001286779.1	Gene:	egl / 37757	FlyBaseID:	FBgn0000562	Length:	1004	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	142/753 - (18%)
Similarity:	261/753 - (34%)	Gaps:	179/753 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ALIGNVLHSKDIKGDIKKRQPEEQFEMVQECNDVLFERITTN-----LDIKGGLRRNTQQVVEAQ 139
            |.:.||:..:.......|.:|...|:.....:::..|.:..|     ....|.:..::||..:.|
  Fly   350 APVSNVMGGQSQGFGQPKSEPSSGFDSYVPMSELKLENLCENNYPSANTCYGPINNSSQQTQQVQ 414

  Fly   140 VDVMSSSTSIEPAVASPQTQGTPKAGSWNRTTGTPQRSMVSARLFTAKNIVRPQTQFREPVDNSA 204
            .......   :.|..:|..|   :..|.|:|......::|...|  |:|:.:.    ::.:.|..
  Fly   415 TQQQQQP---QHATQNPAEQ---RLNSVNQTLKQRINTLVIRTL--AENLEKD----KQSLANQQ 467

  Fly   205 QNPFVPRLKEKPNSLKPLALLPEYDDAG------NVQSYLHPYEFELLKFQPPEEQFQKQKPVLP 263
            ..|..|.    .:.:..:|......:||      |..|..:|..   ....|....|......:.
  Fly   468 GGPISPH----ASPVHSIANSSSNQNAGSAANNANSNSNANPNN---ANHSPSHSYFVGDTWKIK 525

  Fly   264 ALMAET-------ELMVVDTVEKLKQALEELRQAPQIAIDVEHHSYRTFMGITCLVQMSTRSKDY 321
            .|...|       .:.|.|.:  ||.|.:  .::..:::|.|..:......||.:...:||.:.:
  Fly   526 VLQNTTVIANVKQSVFVTDII--LKYAAK--NESIVVSLDCEGINLGLKGEITLIEIGTTRGEAF 586

  Fly   322 IFDT----LILRDDMHILNLVLTDPKKLKILHGADLDIEWLQRDLSLYIVNMFDTHRAAKALNMA 382
            :||.    .::.|..  |..||...:.:|::|....|...|.....:.:.|:|||..|...|...
  Fly   587 LFDVQSCPAMVTDGG--LKTVLEHDQVIKVIHDCRNDAANLYLQFGILLRNVFDTQAAHAILQYQ 649

  Fly   383 RLSLAYLLKHYLDL---------------DVDKSLQLAD---WRMRPLPQQLVDYARQDTHFLIY 429
            ..........|:.|               |..|.:...|   |..|||.::::.||..|...||:
  Fly   650 ESGKQVYKAKYISLNSLCEQYNAPCNPIKDQLKQIYRRDQKFWAKRPLTREMMLYAAGDVLVLIH 714

  Fly   430 --VYGRMTND-------LLQQHAEPGLLGSVYQQSTDVCKKRYNKPHIGPESHLDLVRK---TKR 482
              ::|.:...       |..:.....:|..:......:.||:..   :..|.. ||.:|   |.:
  Fly   715 DQLFGNLARQIKPENRALFSELCTEQILMQIKPNEVKIRKKQRK---VSTEVS-DLKQKLAQTSK 775

  Fly   483 S--FDNRQLYALRGIFEWRDATARSEDESYGYVLPNHMMLQIAESLPR-EMQGILACCNPIPPLV 544
            |  ..||::..||    :.|.|...::...||       .::|:.|.: |..|     ||
  Fly   776 SIVLSNREIRLLR----YMDLTEDEKERLKGY-------YKVAKKLEKMESAG-----NP----- 819

  Fly   545 RQQLHTLHQIVLKARDQPLVKPILEAHSSTQAALPPSTKDFSSKLYCPHDFSQLEEIRDDLPTLL 609
                         ::||          |.::....|:..|         .|..|:.:..|
  Fly   820 -------------SKDQ----------SDSEDEQEPNEND---------AFPSLDSVPSD----- 847

  Fly   610 KRNSTTGKLEVPNKEEVAKVDPTLAAPAMALFEK--QSKPTQEEEQRWAHLRKESQTM----RMP 668
              ||.:|........|     |.....:|.:.|:  |:|    ...|.|.:.|....:    .:|
  Fly   848 --NSLSGTFSPRFSSE-----PPSLTESMQMLEEILQNK----SMDRIARIDKLEAILTTATSLP 901

  Fly   669 YKRYLAILPLMVQLKAD-------QLARERSELQK-------RQLCPAAPTVEQN-IKL---EAH 715
            .::.:|...:..||.:.       |:.||:|:..|       |.:.|...|.::. :||   |:.
  Fly   902 CEQIIASNSMQEQLGSSIATTENLQIIREKSKNIKNCNCQGERSVTPIMRTTDKRVVKLVDAESQ 966

  Fly   716 AIGKEDDDMYSVPLKEQLKRKHPQANVKTDPEQQ--PT 751
            .:...|..:..:..:::.:|....|.:...|.::  ||
  Fly   967 TLSTGDVVITKIFFQDEHERAKEAALLSNSPAKRVSPT 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	8/49 (16%)
		Rrp6p_like_exo	268..456	CDD:99850	45/225 (20%)
		rnd	273..622	CDD:130455	77/385 (20%)
		HRDC	485..565	CDD:128635	16/80 (20%)
		MSA_2	735..>833	CDD:144541	5/19 (26%)
egl	NP_001286779.1	Egl_like_exo	541..744	CDD:99851	44/208 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930