DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp6 and Exosc10

DIOPT Version :9

Sequence 1:	NP_001097795.1	Gene:	Rrp6 / 41798	FlyBaseID:	FBgn0038269	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_003750136.1	Gene:	Exosc10 / 313707	RGDID:	1593248	Length:	885	Species:	Rattus norvegicus

Alignment Length:	954	Identity:	331/954 - (34%)
Similarity:	493/954 - (51%)	Gaps:	160/954 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRTPKRVHQEAKEESA-QADQPPKKSASEDVEAFTNKGFKNAIAATKAANAFPQ-GTARALYLSY 64
            |.:| |.||.|....| :.|.........|.::|......:.:|.|||:...|| |.....|.|:
  Rat     3 PPSP-REHQSAPATGATKPDAEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQVGDEYDFYRSF 66

  Fly    65 PGYARVMEDLTQRVVALIGNVLHSKDIKGDIKKR----QPEEQFEMVQECNDVLFERITTNLDIK 125
            |.:....|....|::..:..|:.....:.:||.|    :.|::|:::.:.|||:.||:...||..
  Rat    67 PAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDTNDVILERVGILLDEA 131

  Fly   126 GGLRRNTQQVVEAQVDVMSSSTSIEPAVASPQTQGTPKAGSWNRTTGT--PQRSMVSARLFTAKN 188
            .|:.::.|.|:.|.:.|..:..|                 ||||..|.  .:....:.||..|||
  Rat   132 SGVNKHQQPVLPAGLQVPKTIVS-----------------SWNRKAGEYGKKAKAETFRLLHAKN 179

  Fly   189 IVRPQTQFREPVDNSAQNPFVPRLKEKPNSLKPL--ALLPEYDD--------------------- 230
            |:|||.:|||.:||| ..||:|::..|||:.|||  ||..|..:
  Rat   180 ILRPQLRFREKIDNS-NTPFLPKIFVKPNARKPLPQALSKERRERPQDRPEDLDVPPALADFIHQ 243

  Fly   231 --AGNVQS--YLHPYEFELLKFQPPEEQFQKQKPVLPALMAETELMVVDTVEKLKQALEELRQAP 291
              |..|:.  :.|||::||..|.||....|:.:|.|...:.||...||.::::|.:..|:|....
  Rat   244 QRAQQVEQDVFAHPYQYELDHFTPPPSVLQRPQPQLYRPVEETPCHVVSSLDELVELNEKLLGCQ 308

  Fly   292 QIAIDVEHHSYRTFMGITCLVQMSTRSKDYIFDTLILRDDMHILNLVLTDPKKLKILHGADLDIE 356
            :.|:|:||||||:|:|:|||:|:|||::|:|.|||.||.||:|||..||||..:|:.||||.|||
  Rat   309 EFAVDLEHHSYRSFLGLTCLMQISTRTEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIE 373

  Fly   357 WLQRDLSLYIVNMFDTHRAAKALNMARLSLAYLLKHYLDLDVDKSLQLADWRMRPLPQQLVDYAR 421
            |||:|..||:|||||||:||:.||:||.||.:||:.|..::.:|..||||||:||||:::::|||
  Rat   374 WLQKDFGLYVVNMFDTHQAARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLNYAR 438

  Fly   422 QDTHFLIYVYGRMTNDLLQQ-HAEPGLLGSVYQQSTDVCKKRYNKPHIGPESHLDLVRKTKRSFD 485
            .|||:|:|:|.||..:|.:: :.:|..|..|:|:|.|:|.|::.||....||:|:|.||.|:..:
  Rat   439 DDTHYLLYIYDRMRLELWERGNDQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLN 503

  Fly   486 NRQLYALRGIFEWRDATARSEDESYGYVLPNHMMLQIAESLPREMQGILACCNPIPPLVRQQLHT 550
            ::||.|.:.:|.|||.|||.|||||||||||||||:|||.||:|.|||:|||||:|||||||::.
  Rat   504 SQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINE 568

  Fly   551 LHQIVLKARDQPLVKPILEAHSSTQAALP-----PSTKDFSSKLYCPHDFSQLEEIRDDLPTLLK 610
            :|.::.:||:.||:|      |.|.|.:.     ||.:...:.|:.|||.|....  |:.|.
  Rat   569 MHLLIQQAREMPLLK------SETAAGVKKSGPLPSAERLENDLFGPHDCSHAPP--DNYPV--- 622

  Fly   611 RNSTTGKLEV--------PNKEEVAKVDP--TLAAPAMALFEKQSKPTQEEEQRWAHLRKESQTM 665
             .||.|.:.:        ..|||.: ||.  .||...:.||   |:|:.||..:
  Rat   623 -TSTDGTMPLQKQPSLFDEGKEETS-VDARCLLATAVITLF---SEPSTEEAGK----------- 671

  Fly   666 RMPYKRYLAILPLMVQLKADQLARERSELQKRQLCPAAPTVEQNIKLEAHAIGKEDDDMYSV--- 727
                      .||.|..|..|...|..|...|..   .|::|....:...|.......:|.:
  Rat   672 ----------TPLTVAQKKAQSIMESFENPFRMF---LPSLENKAHISQAAKFDPSSKIYEISNR 723

  Fly   728 -PLKEQLKRKHPQANVKTDPEQQPTASKRPRKDENSQTKPPVKIEPVEKVQQALGESDDEVVEVP 791
             .|..|::::..:|..|...||  ||::...|:|::..   |..:|:...|||..|:..:..|
  Rat   724 WKLASQVQKEPKEAAKKKVAEQ--TAAREETKEESTAA---VLEQPIPVRQQAALENATKKRE-- 781

  Fly   792 IERQATEPPKPSPAQNNRKQKKNQFQRGFKAKNRGNHPQSSSQQVPQHKGTGNFDYKNVDFRQFK 856
               :||...:..    .:||:|.:.:...|||:    |.      |..|....:||...||..|.
  Rat   782 ---RATSDLRTI----EQKQEKKRLKSSKKAKD----PD------PPGKDFSPYDYSQSDFGAFA 829

  Fly   857 GGAQRARGTEIKQQIRGKNRPNNRNNKQFNKLFTFSNVRKEGKK 900
            |.:              |::|:::        |..:.|...|||
  Rat   830 GDS--------------KSKPSSQ--------FDPNKVAPSGKK 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp6	NP_001097795.1	PMC2NT	55..125	CDD:285328	19/73 (26%)
		Rrp6p_like_exo	268..456	CDD:99850	99/188 (53%)
		rnd	273..622	CDD:130455	177/362 (49%)
		HRDC	485..565	CDD:128635	51/79 (65%)
		MSA_2	735..>833	CDD:144541	24/97 (25%)
Exosc10	XP_003750136.1	PMC2NT	47..133	CDD:400418	24/85 (28%)
		Rrp6p_like_exo	284..474	CDD:99850	99/189 (52%)
		HRDC	503..583	CDD:128635	51/79 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346243
Domainoid	1	1.000	206	1.000	Domainoid score	I2815
eggNOG	1	0.900	-	-		E1_COG0349
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1469
OMA	1	1.010	-	-		QHG47749
OrthoDB	1	1.010	-	-		D267612at33208
OrthoFinder	1	1.000	-	-		FOG0003372
OrthoInspector	1	1.000	-	-		oto95574
orthoMCL	1	0.900	-	-		OOG6_101473
Panther	1	1.100	-	-	LDO	PTHR12124
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2726
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770