DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3631 and fam20a

DIOPT Version :9

Sequence 1:	NP_650398.3	Gene:	CG3631 / 41797	FlyBaseID:	FBgn0038268	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001124252.1	Gene:	fam20a / 564308	ZFINID:	ZDB-GENE-081022-117	Length:	527	Species:	Danio rerio

Alignment Length:	515	Identity:	147/515 - (28%)
Similarity:	228/515 - (44%)	Gaps:	124/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVASLLGLALGANFYFM--------YYL---------------------------SAEEGHLASV 40
            :||..|...|.|:.:|:        |:|                           |.|:|
Zfish     7 LVAVTLVTLLAADLHFILLPRLKSWYFLPRESCSCGDSNGSVDAMWMWSQNWTAVSIEKG----- 66

  Fly    41 RALENMIRHKMRHLK-PNYLNRNPRFFMFRNKLLKNY---------------KAAPYENASV--- 86
            ..||.:.||.:.::: |:.  |.....:.|.:|:..|               :||...|.|:
Zfish    67 SKLERLFRHPLYNIRLPDL--RADELLLERQELINYYQRKVSRWERMKKFYMEAAAASNISISDH 129

  Fly    87 ---LWDIANWWPHENEV--YPLY---DSSMGQLLETLRREPITRV---------------SNLGR 128
               ....|:|......:  |.||   |||:..||:.::.:.:...               |.:.:
Zfish   130 RVSFKPDASWLQFHLGINRYALYNREDSSVDTLLQDMQTDTVINADFTQDEKALKGACDCSQVVK 194

  Fly   129 --GTQLKLLVRLSHQQKVIFKPQWYPR-EEVIDGMIY-SGKDRHTAEVYAFYLGAVLDFRWTPIV 189
              |..|||.::|....|.:|||....| ||..:...| ....||.||:.||:|..|||||..|.|
Zfish   195 PSGLHLKLALKLQDFGKAMFKPMRQERHEETPENFFYFVDFQRHNAEIAAFHLDRVLDFRRVPPV 259

  Fly   190 VGRVVNLKKEI-YAKGDPELQQTINIETDEDGREKYCLFGKCHY-CNEEETVCGDERHN--IEGV 250
            .||.||:..|| |...:.||:.......    ....|.|.||.| |..|..|||   |.  :||.
Zfish   260 AGRFVNVTSEILYITHNEELRSVFFTSP----ANNTCFFAKCLYVCKSEYAVCG---HPDLLEGS 317

  Fly   251 LIYIVPG-TLAKRRS---PWQRTYKDDKRAPWEDDMTYCKSLKNKM---ETIRLLDLIDASIFDY 308
            :...:|| ::|.|.|   ||.|:|.......||.:.:||.:::...   ...|||::||.::||:
Zfish   318 MSAYLPGLSIAPRISIPNPWIRSYSFTGTEEWEVNPSYCDTVRKHYPYNSGNRLLNMIDMAVFDF 382

  Fly   309 LIQNGDRHHYE--TR--EERVVL-IDNGKAFGNPNKDHLDILAPLYQCCL-----------LRKS 357
            |..|.||||||  |:  :|..:| :||.:.||..:.|.|.|||||.|||:           :::|
Zfish   383 LTGNMDRHHYEIFTKFGDEGFLLHLDNARGFGRHSHDELSILAPLTQCCISAGGVIMCSSRIKRS 447

  Fly   358 TWDRLQVFSGG--VLTEIIDRLSKQDALYPLITDKHKKGVERRLLVVYAVVEHCMDIEGD 415
            |..||::.|..  :|::::.....:|||.|::|::|.:.::|||......|:.|::..|:
Zfish   448 TLFRLKLLSSSEYLLSDVMRESLSRDALSPVLTEEHLQALDRRLKHTLLAVDTCVEKHGE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3631	NP_650398.3	FAM20_C_like	224..414	CDD:297333	75/217 (35%)
fam20a	NP_001124252.1	FAM20_C_like	284..511	CDD:297333	76/231 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227822at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820