DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3631 and fam20b

DIOPT Version :9

Sequence 1:	NP_650398.3	Gene:	CG3631 / 41797	FlyBaseID:	FBgn0038268	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001038283.1	Gene:	fam20b / 557060	ZFINID:	ZDB-GENE-040724-125	Length:	409	Species:	Danio rerio

Alignment Length:	425	Identity:	162/425 - (38%)
Similarity:	229/425 - (53%)	Gaps:	43/425 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRSVIIAGIVASLLGLALGANFYFMYYLSAEEGHLASVRALENMIRHKMRHLKPNYLNRNPRFFM 67
            |:.|::...|..|||||.      ::.|...||..||.|.|...  .||          .....:
Zfish     4 KQRVVVLCAVLFLLGLAK------VFLLDGGEGSAASRRDLRAF--RKM----------EASLSL 50

  Fly    68 FRNKLLKNYKAAPYENASVLWDIANWWPHENEVYPLYDSSMGQLLETLRREPITRVSNLGRGTQL 132
            .:...|.:...:|       |::|..|....||||.....:..:|..|....:.|.....:||||
Zfish    51 AKGARLTHTLQSP-------WEVAAQWVGPREVYPDETPELAAVLNALATAHVERADVGYKGTQL 108

  Fly   133 KLLVRLSHQQKVIFKPQWYPREEVIDGMIYSGKDRHTAEVYAFYLGAVLDFRWTPIVVGRVVNLK 197
            |.|:.|...|||:|||:.|.|:.|::|..|:|.|||.||:.||:|..:|.||..|:||||.:||:
Zfish   109 KALLVLDGGQKVVFKPKRYVRDYVVEGEPYAGYDRHNAEIAAFHLDRILGFRRAPLVVGRFMNLR 173

  Fly   198 KEIYAKGDPELQQTINIETDEDGREKYCLFGKCHYCNEEETVCGDERHNIEGVLIYIVPGT--LA 260
            .||......:|..|..:..:..     |.:|||:||.|.|..|. |...:||.:...:|..  |.
Zfish   174 TEIKPVATDQLLSTFLMHGNNT-----CFYGKCYYCRETEPACA-EGDVMEGSVTLWLPDVWPLQ 232

  Fly   261 KRRSPWQRTYKDDKRAPWEDDMTYCKSLKNKMETI----RLLDLIDASIFDYLIQNGDRHHYETR 321
            |.|.||.|||::.|.|.||.|.:||:::| ||...    ||||:||.|||||||.|.||||||:.
Zfish   233 KHRHPWGRTYREGKLARWEYDESYCEAVK-KMPPYDAGPRLLDVIDTSIFDYLIGNADRHHYESF 296

  Fly   322 EE-----RVVLIDNGKAFGNPNKDHLDILAPLYQCCLLRKSTWDRLQVFSGGVLTEIIDRLSKQD 381
            ::     .::|:||.|:||||:.|...|||||||||::|.|||:||.:..||||:..:.:.:..|
Zfish   297 QDDGGASMLILLDNAKSFGNPSLDERSILAPLYQCCMVRVSTWNRLNLLKGGVLSSAMRQATAHD 361

  Fly   382 ALYPLITDKHKKGVERRLLVVYAVVEHCMDIEGDK 416
            ..:|::|..|...::|||..|.|.|..||:.:|.:
Zfish   362 PAFPVLTGAHLTALDRRLNGVLATVRQCMETQGSE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3631	NP_650398.3	FAM20_C_like	224..414	CDD:297333	91/200 (46%)
fam20b	NP_001038283.1	FAM20B_C	188..394	CDD:198461	91/212 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581821
Domainoid	1	1.000	181	1.000	Domainoid score	I3435
eggNOG	1	0.900	-	-		E1_KOG3829
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8909
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3049
OMA	1	1.010	-	-		QHG49094
OrthoDB	1	1.010	-	-		D227822at33208
OrthoFinder	1	1.000	-	-		FOG0008106
OrthoInspector	1	1.000	-	-		oto40282
orthoMCL	1	0.900	-	-		OOG6_109176
Panther	1	1.100	-	-	LDO	PTHR12450
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810