DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3631 and FAM20A

DIOPT Version :9

Sequence 1:	NP_650398.3	Gene:	CG3631 / 41797	FlyBaseID:	FBgn0038268	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_060035.2	Gene:	FAM20A / 54757	HGNCID:	23015	Length:	541	Species:	Homo sapiens

Alignment Length:	424	Identity:	133/424 - (31%)
Similarity:	204/424 - (48%)	Gaps:	51/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSAEEGHLASVRALENMIRHKMRHLKPNYLNRNPRFFMFRNKLLKNYKAAPYE-NASVLWDIANW 93
            |.||:..|||..||        |:.:......|.|..|:|.::.......|.: .....|...:.
Human   110 LGAEDSLLASQEAL--------RYYRRKVARWNRRHKMYREQMNLTSLDPPLQLRLEASWVQFHL 166

  Fly    94 WPHENEVYPLYDSSMGQLLETLRREPITRV-------SNLG----------RGTQLKLLVRLSHQ 141
            ..:.:.:|......:.:||:.:|..|....       :.||          .|..|||::|.|..
Human   167 GINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDCTQIVKPSGVHLKLVLRFSDF 231

  Fly   142 QKVIFKPQWYPREE--VIDGMIYSGKDRHTAEVYAFYLGAVLDFRWTPIVVGRVVNLKKEIYAKG 204
            .|.:|||....|:|  .:|...:....||.||:.||:|..:||||..|..|||:||:.|||....
Human   232 GKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVT 296

  Fly   205 DPELQQTINIETDEDGREKYCLFGKCHY-CNEEETVCGDERHNIEGVLIYIVPG-TLAKRRS--- 264
            ..|:.|::...:.   ....|.|.||.| |..|..|||:. |.:||.|...:|. .||.|.|
Human   297 KNEILQSVFFVSP---ASNVCFFAKCPYMCKTEYAVCGNP-HLLEGSLSAFLPSLNLAPRLSVPN 357

  Fly   265 PWQRTYKDDKRAPWEDDMTYCKSLK-----NKMETIRLLDLIDASIFDYLIQNGDRHHYE--TR- 321
            ||.|:|....:..||.:..||.::|     |..:  |||::||.:|||:||.|.||||||  |:
Human   358 PWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQ--RLLNVIDMAIFDFLIGNMDRHHYEMFTKF 420

  Fly   322 --EERVVLIDNGKAFGNPNKDHLDILAPLYQCCLLRKSTWDRLQVFSGG--VLTEIIDRLSKQDA 382
              :..::.:||.:.||..:.|.:.||:||.|||:::|.|...||:.:..  .|::::.....:|.
Human   421 GDDGFLIHLDNARGFGRHSHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESLLEDQ 485

  Fly   383 LYPLITDKHKKGVERRLLVVYAVVEHCMDIEGDK 416
            |.|::|:.|...::|||..:...||.|:...|.:
Human   486 LSPVLTEPHLLALDRRLQTILRTVEGCIVAHGQQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3631	NP_650398.3	FAM20_C_like	224..414	CDD:297333	75/206 (36%)
FAM20A	NP_060035.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..90
FAM20A	NP_060035.2	FAM20A_C	306..522	CDD:198460	76/220 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227822at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820