DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and SV2B

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001309960.1	Gene:	SV2B / 9899	HGNCID:	16874	Length:	683	Species:	Homo sapiens

Alignment Length:	311	Identity:	65/311 - (20%)
Similarity:	113/311 - (36%)	Gaps:	88/311 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAIYA 67
            ::.|:::||. ||:|:::..:||                                     .|:.|
Human    95 YETIMDECGH-GRFQWILFFVLG-------------------------------------LALMA 121

  Fly    68 PFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGS 132
                       |.:|              ::...|...|  ||.:...:.:.|..:|. :.:||.
Human   122 -----------DGVE--------------VFVVSFALPS--AEKDMCLSSSKKGMLGM-IVYLGM 158

  Fly   133 LMGTFTFGVLGDRIGRVR--AVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFI 195
            :.|.|..|.|.|::||.|  ::.||....|..  |:::......|...|.|||:.......::|.
Human   159 MAGAFILGGLADKLGRKRVLSMSLAVNASFAS--LSSFVQGYGAFLFCRLISGIGIGGALPIVFA 221

  Fly   196 LVLEYLAPKLRNMAISGTLGICFCLGALVAP-----------WLSVLAGN-----WRIYLTCSAL 244
            ...|:|:.:.|...:| .|||.:..|.|.|.           |...:..|     ||:::...||
Human   222 YFSEFLSREKRGEHLS-WLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCAL 285

  Fly   245 LQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAF 295
            ...|..:....:.||.::|:.....:.|...||.: |...|..|....:.|
Human   286 PCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQV-HDTNMRAKGTPEKVF 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	63/303 (21%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	47/188 (25%)
SV2B	NP_001309960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
SV2B	NP_001309960.1	Sugar_tr	8..683	CDD:331684	65/311 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910