Protein Alignment CG14857 and SLC22A14

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 135/557 - (24%)
• Similarity: 237/557 - (42%)
• Gaps: 86/557 - (15%)

  Fly     3 FDQILEKCGSAGRYQYLMILL-------------LGYIAFTTTVHYYSQNIIGFVPQHWCYHEAL 54
            |..:|:..|..|.:|..::.|             ..:..||....|.:.:.|..|..|....|.|
Human   133 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQL 197

  Fly    55 ENRSFEEIAAIYAPFGKEASC-------TRLDKIEGDRVTVSNETCQ-RWIYNYDFGFRSMNAEL 111
                  .:....||.|...:|       ..||.|....:. ..:||| .|||. |...||:..|.
Human   198 ------NLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLN-DTDTCQDGWIYP-DAKKRSLINEF 254

  Fly   112 NWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQ----CGFVGDFLTTYASNL 172
            :.||....|....|.:|..|..:|:..|.::.|::||..|::|:..    .||...|:.::...|
Human   255 DLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYL 319

  Fly   173 -VQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC-FCLGALVAPWLSVLAGNW 235
             .:|.|.:.:.|.|.::     ..|..|:|..:.|..||  .||.| |.:||::...::....:|
Human   320 FFRFGISQSVVGYAISS-----ISLATEWLVGEHRAHAI--ILGHCFFAVGAVLLTGIAYSLPHW 377

  Fly   236 RIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCI 300
            ::......:|.:....:.:::.||.:||:.:..|:.|...|.:.|..|...:.:        |.:
Human   378 QLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPS--------NLL 434

  Fly   301 VKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAV 365
            .:.:|..:....|.:.|..:...|.||:|::...:...|.::.|:|..:..:|:|..     |..
Human   435 DELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVH-----FRH 494

  Fly   366 VVP-----PSGFIQGLLQSRVGRKATAFLAMLCTGLLSCAL---------GVAL------STEGA 410
            |||     |:......|..::|||.:..:.:| ..::.|.|         |:.|      :||
Human   495 VVPSIMEVPARLCCIFLLQQIGRKWSLAVTLL-QAIIWCLLLLFLPEGEDGLRLKWPRCPATE-- 556

  Fly   411 QKNVTLLLAFALPMRLGISMCYTVTSQF--ASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLG 473
            .|::|:|:.    |....|:..|||..|  .:|||||.:|:.|:..|.||:...:.:|..:|...
Human   557 LKSMTILVL----MLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQT 617

  Fly   474 TKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITL 510
            ..|  .|..:..:|.:.|...:.:||||.::.|..:|
Human   618 PSL--LPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	132/546 (24%)
SLC22A14	XP_006713479.2	MFS_OAT	229..641	CDD:340932	108/442 (24%)