DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	151/560 - (26%)
Similarity:	239/560 - (42%)	Gaps:	80/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC-YHEALENRSFEEI-A 63
            |.|:.:|:|.|..|.:|...::|:........:|:.....:..||.|.| ...|..|.|.::: .
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWL 65

  Fly    64 AIYAP---FGKEASCTRL------------------DKIEGDRVTVSNETC-QRWIYNYDFGFRS 106
            ..:.|   .|..:||.|.                  .:.||:.:||   .| |.|.|:......:
  Rat    66 EAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTV---PCSQGWEYDRSEFSST 127

  Fly   107 MNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASN 171
            :..|.:.||......:|..:.||:|.|:|...:|.|.||.||.|.:::|.....|...::..:.|
  Rat   128 IATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASIN 192

  Fly   172 LVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCL-GALVAPWLSVLAGNW 235
            .:.|.:.|.::|.|......::..|.||:|  .:.:..::|.:...|.. |.|:...:..|..:|
  Rat   193 YIMFVVTRTLTGSALAGFTIIVLPLELEWL--DVEHRTVAGVISTVFWSGGVLLLALVGYLIRSW 255

  Fly   236 RIYLTCSALLQLV---VALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADF--EAF 295
            | :|..:|.|..|   :::::  |.|||:||:|:..||.|...|...|..||..|.....  ||.
  Rat   256 R-WLLLAATLPCVPGIISIWW--VPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEAL 317

  Fly   296 RRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVF 360
            .....::|.|     |.....||.||..||.:||..:..:...:.|:..::.:|.|:||:.:...
  Rat   318 NNVVTMERAL-----QRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQ 377

  Fly   361 SLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTL-----LLAF 420
            .||..|..||..:...|..|:||:.|.      .|:|   ||.|| |.|....|:|     :.|.
  Rat   378 LLFGAVELPSKIMVYFLVRRLGRRLTE------AGML---LGAAL-TFGTSLLVSLETKSWITAL 432

  Fly   421 ALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILA 485
            .:..:......:|....|.|||.||.:|..|:....|..           .||..||...:|:..
  Rat   433 VVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMG-----------RLGASLAPLAALLDG 486

  Fly   486 LLLL----------TASGCT-LMLPETNNRQLPITLADGE 514
            :.||          ..:.|| |:||||...|||.|:.|.|
  Rat   487 VWLLLPKVAYGGIALVAACTALLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	144/543 (27%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	98/354 (28%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	144/543 (27%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	109/397 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960