DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and HXT2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_013724.1	Gene:	HXT2 / 855023	SGDID:	S000004613	Length:	541	Species:	Saccharomyces cerevisiae

Alignment Length:	525	Identity:	112/525 - (21%)
Similarity:	185/525 - (35%)	Gaps:	133/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 WIYNYDFGFRSMNAELNWVCNDAYKARIGQ------------------SLFFLGSLMGTFTFGVL 142
            :::.:|.|..|     .:|....:|.|.||                  .:|.:|...|..|.|.|
Yeast    68 FVFGWDTGTIS-----GFVNQTDFKRRFGQMKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGRL 127

  Fly   143 GDRIGR---VRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPK 204
            ||..||   :..|:|....|.|....:  :....|:.|.|.|||:.......|...|:.| .|||
Yeast   128 GDMYGRRIGLMCVVLVYIVGIVIQIAS--SDKWYQYFIGRIISGMGVGGIAVLSPTLISE-TAPK 189

  Fly   205 -LRNMAISG-----TLGIC--FCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQ 261
             :|...:|.     ||||.  :|.......:.:.:  .||:.|..:....:.:.....:|.||.:
Yeast   190 HIRGTCVSFYQLMITLGIFLGYCTNYGTKDYSNSV--QWRVPLGLNFAFAIFMIAGMLMVPESPR 252

  Fly   262 WLITRTNVEGAIARLKHIAHFNGMEVK----AADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTP 322
            :|:.:...|.|   .:.:|..|.:.::    .|:.:....|...:|...|     |...:|..
Yeast   253 FLVEKGRYEDA---KRSLAKSNKVTIEDPSIVAEMDTIMANVETERLAGN-----ASWGELFS-- 307

  Fly   323 NLRKVSLL--VVFTFMLTSLS----------FNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQG 375
              .|.::|  |:...|:.||.          :.|...|..||..| |....:..:|...|.|:..
Yeast   308 --NKGAILPRVIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMKDS-FQTSIVLGIVNFASTFVAL 369

  Fly   376 LLQSRVGRKATAFLAMLCTGLLSCALG---------VALSTEG---------------AQKNVTL 416
            ....:.||:             .|.||         |..||.|               |..||.:
Yeast   370 YTVDKFGRR-------------KCLLGGSASMAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVMI 421

  Fly   417 LLAFALPMRLGIS---MCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTK-LA 477
            :..........||   :.|.:    .:|..|..|::|.:|    .|.||:::..:||...|. :.
Yeast   422 VFTCLFIFFFAISWAPIAYVI----VAESYPLRVKNRAMA----IAVGANWIWGFLIGFFTPFIT 478

  Fly   478 AAPSLILALLLLTASGCTL--------MLPETNNRQLPITLAD-GEAFGKGESMLSFDCWRRHDD 533
            :|.......:.:   ||.:        .:.||..    :||.: .|.:.:|........|...:.
Yeast   479 SAIGFSYGYVFM---GCLVFSFFYVFFFVCETKG----LTLEEVNEMYVEGVKPWKSGSWISKEK 536

  Fly   534 DVSKE 538
            .||:|
Yeast   537 RVSEE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	104/493 (21%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	88/397 (22%)
HXT2	NP_013724.1	Sugar_tr	59..519	CDD:395036	107/501 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000