DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	133/550 - (24%)
Similarity:	237/550 - (43%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAG----RYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEE 61
            ||.|:.....|..|    |....:.||..|:|..:.:..    ::|.||::
Frog     1 MDLDEAFLYIGEFGCCQKRLTAFLTLLQVYVACQSMLIV----LVGAVPEY-------------- 47

  Fly    62 IAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQS 126
                              .|:.:.::.|.|...:.:::.: .|.|:.:|.:.:.|:|||..:..|
Frog    48 ------------------LIDNEDISASKEEYTKHLHDTN-NFTSIVSEWHLIKNEAYKVNLASS 93

  Fly   127 LFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGD----FLTTYASNLVQFAIFRCISGLAAT 187
            |||.|.|:|...||.|.|::|| |.|.|:   |...|    :.|..|.:...||:.|...|:...
Frog    94 LFFAGLLIGNILFGPLSDKLGR-RPVYLS---GLFFDITFGYCTALAPSYEVFAVSRFFVGIMNG 154

  Fly   188 ANYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVAL 251
            ....:.|:|..||:....  .|::|:| .:.|.:|......|.....|||.....:....:...|
Frog   155 GMALVSFVLTQEYVGKSY--WALTGSLTNLIFAVGIAFYALLGFYIRNWRTLAFVANSPGIFFFL 217

  Fly   252 FYFVVQESAQWLITR---TNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKL--SNQPEQ 311
            ..|::.||.:||.:.   |..||.   |:.:|..||:|           ..:||.|.  ....:.
Frog   218 LSFLLPESPRWLYSHGYTTEAEGV---LQSMAVGNGVE-----------RPVVKLKSCPGTSSKS 268

  Fly   312 TAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPS-----G 371
            ...:|||::...||..::|:::.:.:.||.:..::.|...:..:.::..:|:.:|..|:     .
Frog   269 AHSVFDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLCLY 333

  Fly   372 FIQGLLQSRVGRKATA-FLAMLCTGLLSCALGVAL-STEGAQKNVTLLLAFALPMRLGISMCYTV 434
            ||:.....|  ||||| ||..  .| .:|...:.| .|.|...|.|:|..|.   :|.:|..:.|
Frog   334 FIEKSWSGR--RKATAGFLGF--AG-FACIFTIFLPETNGDLLNPTVLALFG---KLSVSAAFNV 390

  Fly   435 TSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLP 499
            ...:.|||.||.||:.|:....:|......:||::..:.:...:.|.:...:..::|...:|:||
Frog   391 VYIYTSELYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLLLP 455

  Fly   500 ETNNRQLPITLADGEA-----FGKGESMLS 524
            ||.|:.:..::.|.::     ..:|..:|:
Frog   456 ETRNKPIAESIEDLQSPAYQLLSRGNEVLA 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	127/518 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	99/360 (28%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	112/435 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920