Protein Alignment CG14857 and SLC22A4

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 140/543 - (25%)
• Similarity: 238/543 - (43%)
• Gaps: 60/543 - (11%)

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC-------YHEALENRSF 59
            |:|:::...|..|.:|.|:..||.........:..|...:...|:|.|       ...|..|.|
Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNS- 66

  Fly    60 EEIAAIYAPF----GKEA--SCT--RLDKI------------EGDRVTVSNETC-QRWIYNYDFG 103
                   .|.    |:|.  ||:  ||..|            :.|...:..|:| ..|.::.|..
Human    67 -------VPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVY 124

  Fly   104 FRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGR--VRAVILANQCGFVGDFLT 166
            ..::..|.|.||.|.:|..:..||||:|.|:|:|..|.|.||.||  |....:|.|.||  .||.
Human   125 LSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGF--SFLQ 187

  Fly   167 TYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC--FCLGALVAPWLS 229
            .::.:...|.:...|.|:...:||.:.|||..|.|...:|  .|..|||:|  |.:|.::.|..:
Human   188 IFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR--IIFSTLGVCTFFAVGYMLLPLFA 250

  Fly   230 VLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEA 294
            ....:||:.|....:..::....::.:.||.:|||::.....|...::..|..|.:.|.|..|::
Human   251 YFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDS 315

  Fly   295 FRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVV 359
            .       .:|:...:|.|.|.||.||.|:..::::.:..:||||:.:..:|.:...:....::.
Human   316 V-------EELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLN 373

  Fly   360 FSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPM 424
            ..|.|::..|:.....||...:.|:      .:...:|....||.|..:....:. ..|:..|.|
Human   374 CFLSALIEIPAYITAWLLLRTLPRR------YIIAAVLFWGGGVLLFIQLVPVDY-YFLSIGLVM 431

  Fly   425 --RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALL 487
              :.||:..:::...|.:||.||.||:..:.....|:...|.::||.::||......|.:::..|
Human   432 LGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSL 496

  Fly   488 LLTASGCTLMLPETNNRQLPITL 510
            .:.....||..||:....||.||
Human   497 TVLIGILTLFFPESLGMTLPETL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	136/531 (26%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	136/531 (26%)