Protein Alignment CG14857 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 150/584 - (25%)
• Similarity: 247/584 - (42%)
• Gaps: 83/584 - (14%)

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQH-WC---YHEALENR---SFE 60
            ||:.|::.|..||:|..:.|||.....|....:.....:|..|.| ||   ...||..|   |.|
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly    61 EIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWI---------------------------- 97
            |      .:.:.|..:|     |.........|||::
Human    69 E------EWNRTAPASR-----GPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122

  Fly    98 --------YNYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL 154
                    :.|.....::.:|.:.||.:|:...:.|::..||.|.|.||.|...||.||:  ||.
Human   123 PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI--VIY 185

  Fly   155 ANQCGFVG--DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC 217
            ...|..||  ..:..:|.|...|.|||.:.|:.....:...:::|.|.:..|.|.: :...:.:.
Human   186 LLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI-VGIVIQMF 249

  Fly   218 FCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHF 282
            |.||.::.|.::....||:.......|...:..|:|:||.||.:|||||...:.|:..|:.||..
Human   250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKC 314

  Fly   283 NGMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISR 347
            ||..:.:    .:....:...::||     ....||:|||.:||.:|:::|.:..:::.:..:..
Human   315 NGKYLSS----NYSEITVTDEEVSN-----PSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM 370

  Fly   348 NVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQK 412
            .:..:|.:.::.|.:..||..|...:..|...|:||:.....:.:..| ::| |..|...||.
Human   371 RLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAG-VAC-LVTAFLPEGI-- 431

  Fly   413 NVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLA 477
             ..|....|...||||:|.:.:.....|||.||.:|:.|::...........::|:|:.   :||
Human   432 -AWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF---RLA 492

  Fly   478 AA----PSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSK 537
            |.    |.:|..:|.....|..::||||....||.|:.|.|..|   |..|..|.|.....||:
Human   493 AVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG---SPHSCKCGRNKKTPVSR 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	137/546 (25%)
		MFS	126..470	CDD:119392	92/345 (27%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	137/546 (25%)
		MFS	149..518	CDD:119392	102/388 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950