Protein Alignment CG14857 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 150/584 - (25%)
• Similarity: 247/584 - (42%)
• Gaps: 83/584 - (14%)

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQH-WC---YHEALENR---SFE 60
            ||:.|::.|..||:|..:.|||.....|....:.....:|..|.| ||   ...||..|   |.|
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly    61 EIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWI---------------------------- 97
            |      .:.:.|..:|     |.........|||::
Human    69 E------EWNRTAPASR-----GPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122

  Fly    98 --------YNYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL 154
                    :.|.....::.:|.:.||.:|:...:.|::..||.|.|.||.|...||.||:  ||.
Human   123 PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI--VIY 185

  Fly   155 ANQCGFVG--DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC 217
            ...|..||  ..:..:|.|...|.|||.:.|:.....:...:::|.|.:..|.|.: :...:.:.
Human   186 LLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI-VGIVIQMF 249

  Fly   218 FCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHF 282
            |.||.::.|.::....||:.......|...:..|:|:||.||.:|||||...:.|:..|:.||..
Human   250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKC 314

  Fly   283 NGMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISR 347
            ||..:.:    .:....:...::||     ....||:|||.:||.:|:::|.:..:::.:..:..
Human   315 NGKYLSS----NYSEITVTDEEVSN-----PSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM 370

  Fly   348 NVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQK 412
            .:..:|.:.::.|.:..||..|...:..|...|:||:.....:.:..| ::| |..|...||.
Human   371 RLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAG-VAC-LVTAFLPEGI-- 431

  Fly   413 NVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLA 477
             ..|....|...||||:|.:.:.....|||.||.:|:.|::...........::|:|:.   :||
Human   432 -AWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF---RLA 492

  Fly   478 AA----PSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSK 537
            |.    |.:|..:|.....|..::||||....||.|:.|.|..|   |..|..|.|.....||:
Human   493 AVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG---SPHSCKCGRNKKTPVSR 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	137/546 (25%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	137/546 (25%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		2/3 (67%)