DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_071606.1	Gene:	Slc22a4 / 64037	RGDID:	621149	Length:	553	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	139/573 - (24%)
Similarity:	254/573 - (44%)	Gaps:	58/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQH-------------WCYHE- 52
            |:|:::...|..|.:|.|:..||.........:..|...:...|:|             |..|.
  Rat     3 DYDEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    53 ALENRSFEEI-----------AAIYAPFGKEASCTRLDKIEGDRVTVSNETC-QRWIYNYDFGFR 105
            .||.:...::           .|.::..|.|..      ::.|...:..|:| ..|.|:.|....
  Rat    68 PLETKDGRQVPQSCRRYRLATIANFSALGLEPG------LDVDLEQLEQESCLDGWEYSKDVFLS 126

  Fly   106 SMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVI--LANQCGFVGDFLTTY 168
            ::..|.|.||.|.:|..:..||||:|.|.|:|..|.|.||.||.:.:.  :|.|.||  .|:..:
  Rat   127 TIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGF--SFVQIF 189

  Fly   169 ASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC--FCLGALVAPWLSVL 231
            ::|...|.:...|.|:...:||.:.|||..|.|:..:|  .:..|||:|  |.:|.:|.|..:..
  Rat   190 STNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVR--ILFSTLGVCTFFAIGYMVLPLFAYF 252

  Fly   232 AGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFR 296
            ..:||:.|....|..|.....::.:.||.:|||::...|.|...::..|..||:...|..|:.
  Rat   253 IRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDP-- 315

  Fly   297 RNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFS 361
               :..::|::..:|...|.||.:|.|:..::::.|..:||||:.:..:|.||..:....::...
  Rat   316 ---LELQELNSLKQQKVFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNCF 377

  Fly   362 LFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLL-LAFALPMR 425
            |..::..|:.|...||...:.|:      .:..|:|....||.|..:...::...: :...:..:
  Rat   378 LSGLIEVPAYFTAWLLLRTLPRR------YIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGK 436

  Fly   426 LGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLT 490
            .|::..:::...|.:||.||.||:..:....:|:...|.::||.::||......|.:::..|.:.
  Rat   437 FGVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVL 501

  Fly   491 ASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEV 543
            ....||..||:....||      |...:.:.:..|.|.::....:.:|...:|
  Rat   502 IGIITLFFPESFGVTLP------ENLEQMQKVRGFRCGKKSTVSMDREENPKV 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	132/528 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	94/348 (27%)
Slc22a4	NP_071606.1	2A0119	12..519	CDD:273328	132/533 (25%)
Slc22a4	NP_071606.1	MFS	123..510	CDD:119392	106/401 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020