DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and Slc22a17

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001347335.1	Gene:	Slc22a17 / 59049	MGIID:	1926225	Length:	520	Species:	Mus musculus

Alignment Length:	541	Identity:	141/541 - (26%)
Similarity:	207/541 - (38%)	Gaps:	115/541 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SQNIIGFVPQHWCYHEAL----------ENRSFEEIA-AIYAPFGKEASCTRLD-KIEGDRVTVS 89
            |..|....|...|::.||          .|.|...:| |..|........|..| ...|......
Mouse     3 SDPIFTLAPPLHCHYGALPPNASGWEQPPNSSGVSVAGAALAASAASGVVTSTDPSCSGFAPPDF 67

  Fly    90 NETCQRWIYNYDFGFRSMNAELNW--VCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAV 152
            |...:.|.|| .....:.||...|  ||:..::..:.|.||.||...|....|...||.|| |.:
Mouse    68 NHCLKDWDYN-GLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGR-RGI 130

  Fly   153 I-----LANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLR-NMAIS 211
            :     |...||..|    ..|.:.......|.:.|.........::::.||...|..| .:|::
Mouse   131 VLLTLGLVGPCGVGG----AAAGSSTGIMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALA 191

  Fly   212 GTL----GICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFY-----FVVQESAQWLITRT 267
            |.|    |....||      |::::.:|| :|........::.|||     |:  |||:|||.:.
Mouse   192 GELVGVGGHFLFLG------LALVSKDWR-FLQRMITAPCILFLFYGWPGLFL--ESARWLIVKR 247

  Fly   268 NVEGAIARLKHIAHFN-------GMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLR 325
            .:|.|.:.|:.:|..|       |.|.:.| .:.....|.:      ....|.....||...|:.
Mouse   248 QIEEAQSVLRILAERNRPHGQMLGEEAQEA-LQELENTCPL------PATSTFSFASLLNYRNIW 305

  Fly   326 KVSLLVVFTFMLTSLSFNTISRNVE------GMGLSP--FVVFSLFAVVVPPSG-------FIQG 375
            |..|::.||        |.|:..:.      |.|.||  |.:.||.|     ||       |: |
Mouse   306 KNLLILGFT--------NFIAHAIRHCYQPVGGGGSPSDFYLCSLLA-----SGTAALACVFL-G 356

  Fly   376 LLQSRVGRKATAFLAMLCTGLLSCAL--------GVALSTEGAQKNVTLLLAFALPMRLGI--SM 430
            :...|.||:....|:|..||:.|..|        ..|::|            |::   ||:  |.
Mouse   357 VTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITT------------FSV---LGLFSSQ 406

  Fly   431 CYTVTSQ-FASELLPTCVRSRGIAAV-HLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASG 493
            ...:.|. .|||::||.||.||:..: .|.|.|........:|:|.. |....::||...|....
Mouse   407 ASAILSTLLASEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHG-AFLQHVVLAACALLCIL 470

  Fly   494 CTLMLPETNNRQLPITLADGE 514
            ..::||||..:.||..|.|||
Mouse   471 SIMLLPETKRKLLPEVLRDGE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	137/534 (26%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	101/392 (26%)
Slc22a17	NP_001347335.1	MFS_SLC22A17	63..476	CDD:341003	117/464 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030