DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	559	Identity:	142/559 - (25%)
Similarity:	245/559 - (43%)	Gaps:	85/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNII--GF----------VPQH------ 47
            :|:|::....|..|.:|.|:..||            |.:||  ||          :|:|
Mouse     2 LDYDEVTAFLGEWGTFQRLIFFLL------------SASIIPNGFTGLSAVFLTAIPEHRCRIPD 54

  Fly    48 -------WCYHE-ALENRSFEEI--------AAIYAPF-------GKEASCTRLDKIEGDRVTVS 89
                   |..|. .:|.:...|:        .|..|.|       |::....:|::
Mouse    55 TVNLSSAWRNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQ--------- 110

  Fly    90 NETC-QRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVI 153
             |.| ..|.|:.|....::..|.:.||.|.:||.:..|.|::|.|:|:|..|.|.||.||...:.
Mouse   111 -ENCLDGWEYDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILF 174

  Fly   154 L--ANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGI 216
            |  |...||  .|:..::.|...|.:...:.|:...:||...|:|..|.|:..:|  .|..|||:
Mouse   175 LTMAMHTGF--SFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVR--IIFATLGV 235

  Fly   217 C--FCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHI 279
            |  |..|.:|.|..:.....||..|....|..::....::.:.||.:|||::..::.|...::..
Mouse   236 CIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKA 300

  Fly   280 AHFNGMEVKAADFEAFRRNCIVKRKL---SNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLS 341
            |..||:...:..|:....|     ||   |::..|:..|:||:||||:|.::::.:..::..|:.
Mouse   301 AKINGIVAPSTIFDPSETN-----KLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVG 360

  Fly   342 FNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALS 406
            :..:|.:...:..:.:|...|.|.|..|:..:..||...|.|:.:...::...|  |..|.|.|.
Mouse   361 YFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGG--SVLLLVQLV 423

  Fly   407 TEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIH 471
            ........|.|:...   :.||:..|::...:.:||.||.||:.|:.....|:...|.:|||.::
Mouse   424 PSDLHYLSTTLVMVG---KFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY 485

  Fly   472 LGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITL 510
            ||......|.:::..|.:..:..||..||::...||.|:
Mouse   486 LGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	139/546 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	96/350 (27%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	139/546 (25%)
		MFS	123..513	CDD:119392	108/403 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950