DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a16

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	596	Identity:	140/596 - (23%)
Similarity:	245/596 - (41%)	Gaps:	81/596 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC----------YHEALENRS 58
            :::.::.|...|:|..:.....:.|.:..:||.:...:...|:..|          |    :|.|
Zfish     6 ERLFDELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCNPPLNITDVLY----KNLS 66

  Fly    59 FEEIAAIYAPF-------------GKE---ASC---TRLDKIE------GDRVTVSNETCQRWIY 98
            |..:|.|:..:             |.:   :.|   .|||.|.      |::   |.|:|..::|
Zfish    67 FTSLADIWTHYKTGDGPVVVRTSQGDQWELSPCLKALRLDAINFQYEFFGNK---SVESCGAFVY 128

  Fly    99 NYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQ-CGFVG 162
            ::....:|:..:.:.||...:.|::.|..|.||.|:|...||...||||| |.|::|.. |.|:.
Zfish   129 DHSEVEQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGR-RPVLMATSLCQFIF 192

  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYL--MFILVLEYLAPKLRNMAISGTLGICFCLGALVA 225
            .....:..|...|.:.|.:  ||..::.||  :|:.|.|:...|:|... |..:...|.:|.:|.
Zfish   193 GVTVAFTGNYYLFVVMRFL--LATVSSGYLVVVFVYVTEFTGIKVRTWT-SMHVHAAFAVGIMVV 254

  Fly   226 PWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGM--EVK 288
            ..:..|...|.||.....|......|:.:...|:..:|:.:...:.|...|..:|:.||:  .:|
Zfish   255 ALVGYLVRVWWIYQIILTLSTSPFLLYCWKFPETPFYLMAKGRYKEAQELLDTMAYINGLPPTLK 319

  Fly   289 AADF-EAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGM 352
            .:|. :...|..:...|.:.:.|:...:.|:..:..:...|......:.:.||.:...|.....:
Zfish   320 VSDLQDGCDRTPLKDNKQAMEVEKRLSMLDMFGSLKMAGRSATCWAIWFIGSLGYYVFSLGSVNL 384

  Fly   353 GLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLL 417
            |.:.::...|...|..||..|......|.|||.|...|:|..| ::|.|.:.:..:.....:.|.
Zfish   385 GGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGG-VACMLIIVVPQDVEVLAIVLS 448

  Fly   418 LA--FALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAP 480
            :.  ||:.:..|:...||      .||.||.:||..:.:..:.....|.|:|:.::|.......|
Zfish   449 MTGKFAIAIAFGLIYLYT------CELYPTIIRSLAVGSGSMMCRVGSVVAPFCVYLADIWIYLP 507

  Fly   481 SLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATE--EV 543
            .||:.:|.......|:.||||....|..||.:.||.|                  ||..|:  ||
Zfish   508 QLIVGILAFIIGILTMFLPETLGEPLTSTLEEAEALG------------------SKPNTKNTEV 554

  Fly   544 RLHQLNGQTKS 554
            ...::|...|:
Zfish   555 NALEMNQSIKA 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	128/540 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	87/351 (25%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	128/540 (24%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	93/378 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850