DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a13b

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	580	Identity:	133/580 - (22%)
Similarity:	244/580 - (42%)	Gaps:	64/580 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEAL----ENRSFEE 61
            :||.|||...|..|.:|..:::.:......|..|.:.|........|:|....:    .|.:.|:
Zfish     2 IDFTQILSSVGEFGAFQKRLLVAVCLPNIFTAFHMFGQVFTAISFPHYCNSSWILRQAPNLTEEK 66

  Fly    62 IAAIYAPF---GKEASCTRLDKIEGD-------RVTVSNETCQRWIYNYDFGFRSMNAELNWVCN 116
            ...:..|.   |:..||.....:|.|       .:..:......|:|.......::..|.:.||.
Zfish    67 QLNLTVPLDSKGQYESCKMFTPVEMDIEDIEHYGINTTTSCIDGWVYKAPKDSSTLITEFDLVCE 131

  Fly   117 DAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNL-----VQFA 176
            :...:...||::..|.|:|...||.:.|:.||..|.:|:....|:......::.|:     ::|.
Zfish   132 NKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGVGVAFSPNIYVYIALRFV 196

  Fly   177 IFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC-FCLGALVAPWLSVLAGNWRIYLT 240
            :...|||::...     |:|..|:.....|  |:...|..| |.:|.::...::....|||:
Zfish   197 VGTTISGISINT-----FVLGTEWCGSAKR--ALFTILSHCFFAIGLMLLSGVAYGIRNWRV--- 251

  Fly   241 CSALLQLVVA-------LFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRN 298
                ||||::       ::|:::.|||:||:|:..::.|...:...|..||.:|.        .|
Zfish   252 ----LQLVLSAPVGLFFIYYWILPESARWLLTQGKLDSAKREILKAARINGRKVS--------EN 304

  Fly   299 CIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLF 363
            .:.|.:..|..:.:. :.||.|...|||.:|::.:.:.:|||.:..:|.||...||..::...:|
Zfish   305 LLDKMEAENTAKSST-MIDLFRVGYLRKRALIMCYMWFVTSLVYYGVSLNVGNFGLDIYLTQLIF 368

  Fly   364 AVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGI 428
            .:...|:......|..|.||:....:.:|..| .:|.:..|:..    |...::...|:..:..:
Zfish   369 GMAEFPARLSCFPLIQRFGRRICQSVVLLLGG-TACLIIPAIPA----KYPIVVTVIAVIGKFSL 428

  Fly   429 SMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASG 493
            :..:::...:.:||.||.||..|:....:.|..|..::|.:..|.....|.|.:|...|......
Zfish   429 AASFSIVYVYTAELYPTVVRQNGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGA 493

  Fly   494 CTLMLPETNNRQLPITLADGEAFGKGESM----LSFDCW-RRHDDDVSKEATEEVRLHQL 548
            .|.:||||.|..    |.|.......|||    :..:.| ||...|..:..:::.:..:|
Zfish   494 LTFLLPETLNTD----LQDHTDIPADESMTVTEVKLERWGRRRGWDRERSTSQDFKSGRL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	118/524 (23%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	85/356 (24%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950