DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a23

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001338637.1	Gene:	slc22a23 / 555979	ZFINID:	ZDB-GENE-030131-3564	Length:	942	Species:	Danio rerio

Alignment Length:	572	Identity:	133/572 - (23%)
Similarity:	231/572 - (40%)	Gaps:	119/572 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILEKCGSAGRYQYLMILL-------LGYIAFTTTV---------HYYSQNIIGFVPQHWCYHEAL 54
            :|...|..|:||..:|:|       :|:..|:...         |..|..::...|
Zfish    41 VLPSVGGFGKYQKQLIVLTWIPAIFIGFSQFSDNFLLTNPCPEPHNNSSQLLTVAP--------- 96

  Fly    55 ENRSFEEIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGF-RSMNAELNWVCNDA 118
                 ..::.::.....||:              |...|....|....|. :::..:.|.||:.|
Zfish    97 -----TAVSTVFTGVNTEAA--------------SQCNCTPSSYKLQNGLEQNIVTKWNLVCDSA 142

  Fly   119 YKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFR---- 179
            :|..|.:....:||:.|....|||.|..||...:||:.....|......::.||..|...|
Zfish   143 WKIHIAKFSLLVGSIFGYLVLGVLADWFGRHPVLILSVVFLLVFGMTVAFSVNLPMFGTLRFFEG 207

  Fly   180 -CISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRI---YLT 240
             |::|:..:     :::|.:|...|..| .:|:.........|.|:.|.|:.|..:|:|   .:.
Zfish   208 FCLAGITLS-----LYVLRIELCLPGWR-FSITMVANFMMLAGQLLMPGLAALCRDWQILQAVIV 266

  Fly   241 CSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKL 305
            |..||.|   .:.:...||.:||:.......:...::.|:..|.:.:: .|.|.....  :...|
Zfish   267 CPLLLML---SYIWAFPESLRWLLATQQYSRSKWIMERISKKNNINLQ-EDAEELMTE--LNGAL 325

  Fly   306 SNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSF-NTISRNV---EGMGL--------SPFV 358
            ..||::|. |..::.|.||.| :::|:....||.... :..:|::   :.:|.        :.:.
Zfish   326 QKQPKKTC-IVKMVGTRNLWK-NIVVLCVNSLTGYGIHHCFARSMMEKKTVGFVEKLHDFYAEYY 388

  Fly   359 VFSLFAV--------VVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSC--ALGVALS-TEGAQK 412
            |.::.||        .|...|...|||...:   .||..::|..|||:.  ..|..|| ....:.
Zfish   389 VMAVIAVASCVFLCPAVALMGRRGGLLMFMI---ITALASLLQLGLLNLLGKYGDHLSLVHSDEL 450

  Fly   413 NVTLLLAFALPMRLGISMCYTVTSQ---FASELLPTCVRSRGIAAVHLAAAG-ASFVSP------ 467
            |....:||::   :|:...:.|::.   |.:|:.|:.:|..|:..| ||:|| ....||
Zfish   451 NDKFSVAFSI---IGMFSSHAVSNLSIFFCAEITPSVIRGGGLGLV-LASAGFGMLTSPIMELHN 511

  Fly   468 ---YLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADGEAF 516
               |.:|         .:|.|...|....|.|:||||.|:.||.||:|||::
Zfish   512 QKGYFLH---------HIIFACCTLICIICILLLPETRNQPLPETLSDGESY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	127/558 (23%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	91/387 (24%)
slc22a23	NP_001338637.1	Sugar_tr	<131..547	CDD:331684	110/445 (25%)
slc22a23	NP_001338637.1	Atrophin-1	630..>937	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030