Protein Alignment CG14857 and SLC22A15

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 144/590 - (24%)
• Similarity: 245/590 - (41%)
• Gaps: 83/590 - (14%)

  Fly     1 MDFDQILEKCGSAGRYQ-YLMILLLGYIAFTTTVHYYSQNIIGFVPQ-HWCYHEALENRSFEEIA 63
            |:.::..:..|..|.|| ||..||...:............::|..|. ||...|.|.|:|....:
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQS 65

  Fly    64 AIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLF 128
            |     |:       |:..||.:..:|.:......::...|.|:.:|...:.|.:||.....|.|
Human    66 A-----GE-------DQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFF 118

  Fly   129 FLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQ----FAIFRCISGLAATAN 189
            |.|..:|..:||.|.||.||.:..:    .||..|.|...|:....    ||:.|.:.|:.....
Human   119 FSGVFVGVISFGQLSDRFGRKKVYL----TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGM 179

  Fly   190 YYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTCSALLQL---VVA 250
            ..:.|:|:.|.:....  .|::|:: |:.|.:|......|.....:||   |.:.|:.|   ||.
Human   180 SLVAFVLLNECVGTAY--WALAGSIGGLFFAVGIAQYALLGYFIRSWR---TLAILVNLQGTVVF 239

  Fly   251 LFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKL---------- 305
            |....:.||.:||.::..:..|...|..||               :||    |||
Human   240 LLSLFIPESPRWLYSQGRLSEAEEALYLIA---------------KRN----RKLKCTFSLTHPA 285

  Fly   306 SNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPS 370
            :....:|....||.|...|...:|:::|.:.:.||.:..::.:...:|.|.:...:|..::..||
Human   286 NRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPS 350

  Fly   371 G--FIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLA------FALPMRLG 427
            .  .|..:.|...|||.| ..|.||.|.|:|.:.:.|    .:|..|.:.|      .:|..:|.
Human   351 YPLCIYLINQKWFGRKRT-LSAFLCLGGLACLIVMFL----PEKKDTGVFAVVNSHSLSLLGKLT 410

  Fly   428 ISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTAS 492
            ||..:.:...:.|||.||.:|:.|:....:.:.....::|::..|.....:.|.::.....||:.
Human   411 ISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSG 475

  Fly   493 GCTLMLPETNNRQLPITLADGEAFG---KGESMLSF------DCWRRHDDDVSKEATEEVRLHQL 548
            ..:|:||||.|..|..|.:|.:.:.   .||..||.      .|..: :..:..|:.||...:..
Human   476 LLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDK-ESSLGSESEEEEEFYDA 539

  Fly   549 NGQTK 553
            :.:|:
Human   540 DEETQ 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	132/525 (25%)
SLC22A15	NP_060890.2	MFS_SLC22A15	71..469	CDD:340935	104/430 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547		4/24 (17%)