DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Orct2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	166/602 - (27%)
Similarity:	267/602 - (44%)	Gaps:	83/602 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEAL--ENRSFEEIA 63
            |.:|:.:...|..||||.::..|:...:.....|..:...:...|...|   ||  ||.|..::.
  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRC---ALPFENGSSYDLP 62

  Fly    64 A----IYAPFGKEASCTRLDKIE----GDRVTVSNE--TCQRWIYNYDFGFRSMNAELNWVCNDA 118
            .    :..|..:..|...:|..|    |.....|||  ||..::|:......|...|.|.||...
  Fly    63 THLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRD 127

  Fly   119 YKARIGQSLFFLGSLMGTFTFGVLGDRIGR--------VRAVILANQCGFVGDFLT-TYASNLVQ 174
            :.|....|||.||.|:|:..||.|.|:.||        |..|:.....|...::.| |:|
  Fly   128 FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFA----- 187

  Fly   175 FAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGI----CFCLGALVAPWLSVLAGNW 235
                |.:.|...:..:.:.:::.:|.:.|..|..|     ||    .|.:|.::....:....:|
  Fly   188 ----RLMVGATTSGVFLVAYVVAMEMVGPDKRLYA-----GIFVMMFFSVGFMLTAVFAYFVHDW 243

  Fly   236 RIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADF-----EAF 295
            |.......|..|:...:|:::.|||:||:.:...:.|||.::..|.||.:|:.....     |..
  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGE 308

  Fly   296 RRNCIVKRKLSNQPEQTAG----IFDLLRTPNLRKVSLLVVFTFMLTS-----LSFNTISRNVEG 351
            ......|:||.:| |...|    ::||...||||:.:||:...:::||     ||:||  .|:.|
  Fly   309 NSEEKAKQKLEDQ-ELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNT--SNLGG 370

  Fly   352 MGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTL 416
            ..|..||:..  ||.:|...|:. |..:|.||:     ::||..|:...|.:..:....|:..||
  Fly   371 NVLLNFVISG--AVEIPAYIFLL-LTLNRWGRR-----SILCGCLVMAGLSLLATVIIPQRMHTL 427

  Fly   417 LLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPS 481
            ::|.|:..:|.|:..|.....|::|..||.||:..:.|..:.|..:..::|:|..|.|.....|.
  Fly   428 IVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPL 492

  Fly   482 LILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLH 546
            ||...|.|.|...:|:||||:|:.:..|:||||.|||           :...||..|..:|:|..
  Fly   493 LICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGK-----------KTKADVYLETGQELRAP 546

  Fly   547 QL-----NGQTKSETEA 558
            :.     :|:|...|.|
  Fly   547 EAQPLKGSGETNGSTIA 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	147/536 (27%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	101/370 (27%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	147/536 (27%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	110/400 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	4.990