DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and CG16727

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	204/548 - (37%)
Similarity:	331/548 - (60%)	Gaps:	15/548 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAI 65
            ||||::|||||:.||:|:::::|.||....:::||:||.:|.|.|:|||.|:.|......|:.:|
  Fly     1 MDFDRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHDDLMGLGAAELRSI 65

  Fly    66 YAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFFL 130
            |:.. ...|||.|.::.......|.|:||.||:..:.|:.|:..||.|||:.:::..:|||.|||
  Fly    66 YSNV-SHPSCTLLSEVINGTGVASEESCQDWIFERENGYESLTTELKWVCDKSHQPAVGQSFFFL 129

  Fly   131 GSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFI 195
            ||::||.:||.|.|.|||:.|:::|...|..|||:|::...|..||..|.:|||:....||||:|
  Fly   130 GSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFAFSRFVSGLSTDTMYYLMYI 194

  Fly   196 LVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESA 260
            ||.|||:||.|...::..|.:.:|.|.:.:||:::..||||.||..::|..|.|.::..::.|||
  Fly   195 LVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLWLASLPALGVLIYPLLICESA 259

  Fly   261 QWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAF----RRNCIVKRKLSNQPEQTAGIFDLLRT 321
            |||:|:...:.|:|.||.:|.|||.:|:.:.|:.|    |.....:.||:.|.:...|:|   :|
  Fly   260 QWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKHYREKMNEESKLNKQMDTFLGMF---KT 321

  Fly   322 PNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKAT 386
            |.||:.:..::...::.:||::.|:||:||:|.|||.:|||.:.|..|:||...|||:::|||..
  Fly   322 PRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTSSVYLPAGFTILLLQNKIGRKGM 386

  Fly   387 AFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRG 451
            |..|:|...:::...|..::.....:|..||.......|.|.::.|....|:|:|::||.||.:.
  Fly   387 ACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGRFGTTVSYDAEIQYAAEIIPTSVRGQA 451

  Fly   452 IAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADGEAF 516
            ::.:|:....:|.::.|:|:|.......||:.:::|:...:...|.||||.:::||.||||||.|
  Fly   452 VSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALLCLTLPETLHKKLPETLADGERF 516

  Fly   517 GKGESMLSFDCWRR-------HDDDVSK 537
            ...||.|.|.|..:       |:|..|:
  Fly   517 AMNESCLYFPCLHKRRESLTEHEDRKSE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	181/501 (36%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	128/347 (37%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	181/501 (36%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	134/376 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	9	8.910