DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and CG17752

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_650817.1	Gene:	CG17752 / 42337	FlyBaseID:	FBgn0038718	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	202/556 - (36%)
Similarity:	328/556 - (58%)	Gaps:	21/556 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALE-NRSFEEIAA 64
            ||..::|||||:.|.||.|::.|.||....:::||:||.:|.|.|.|.|.....| :::|.|:
  Fly     1 MDLQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHRCSAPVEEFSQNFTEL-- 63

  Fly    65 IYAPFGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFF 129
                    .||:.: :.:.|..:..:..|..|.::.:..:.|:..||.|||:||||..:|||.||
  Fly    64 --------LSCSVI-QYDVDMTSFRDNKCSSWDFDKESNYESITTELEWVCDDAYKLAVGQSFFF 119

  Fly   130 LGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMF 194
            :||.:|:..||.|.|||||:.|.:|:...|..|||.|::..:|..|:..|.||||:....|.||:
  Fly   120 IGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPMFSFTRFISGLSMDTQYVLMY 184

  Fly   195 ILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQES 259
            |||.|||:|:.|...::..||:.:.:|.:::||:::..||||.||..::|..|.:.:|...:.||
  Fly   185 ILVFEYLSPQHRTFGLNIILGVFYSIGLMISPWIAIWLGNWRSYLWAASLPALGMLIFPLFLHES 249

  Fly   260 AQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIF-DLLRTPN 323
            .:||:|:...:.|:..||.:|.|||.:|:.:.|:.|.::  .:.||::..::::..| .:||||.
  Fly   250 VEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKH--YREKLNSAQKKSSDTFMGMLRTPR 312

  Fly   324 LRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAF 388
            |||.:::::...|:.:::|:.:||||||:|:|||.:||....||.|.|....|.|:::|||..|.
  Fly   313 LRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFVVLPGGLSIILFQNKIGRKGMAC 377

  Fly   389 LAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPM-RLGISMCYTVTSQFASELLPTCVRSRGI 452
            .::|....::...|..:.|.. ..|.::||.|.:.: |.|..:.|...:|:|:|::||.||.||:
  Fly   378 ASLLVGAFITATTGYLVGTLD-PANYSVLLGFMVCLARFGAVVAYDAEAQYAAEIIPTSVRGRGV 441

  Fly   453 AAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFG 517
            |.:|:.....:|.|.|:|:|||.....|||:::.||:..:...|.||||.::|||.||.:||.|.
  Fly   442 ANIHVVGNAFAFFSSYIIYLGTFYKPLPSLLISFLLIIGACLCLTLPETLHKQLPQTLEEGEIFA 506

  Fly   518 KGESMLSFDCWRRHDDDVSKEATEEVRLHQLNGQTK 553
            |||....|.|:.|.......|:    :|...|..||
  Fly   507 KGEKWYFFPCFSRKRQSNKSES----QLESANEITK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	180/500 (36%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	126/345 (37%)
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	180/500 (36%)
CG17752	NP_650817.1	MFS	116..488	CDD:119392	136/374 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.900