DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and CG8925

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	115/510 - (22%)
Similarity:	205/510 - (40%)	Gaps:	65/510 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QILEK-CGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQ-HWCYH-EALENRSFEEIAAIY 66
            ::||: .|....:|.:...||.......|.|.:.. :....|: .||.. |.|...|..|...|
  Fly   148 KLLERLLGCLTPWQSMWCALLSIFQAICTFHIFVY-VFQIAPKDFWCARPENLMQMSVSEWRNI- 210

  Fly    67 APFGKEAS--CTRLDKIEGDRVTVSNETCQRWIYN-YDFGFR---------------SMNAELNW 113
                .::|  |..|| ::..:||..|.....|..| .|.|:|               ::..|.:.
  Fly   211 ----SQSSNGCLLLD-VDYTQVTYENNQLINWPENATDLGYRQCWHFEFSDVDGSAKTLVQEFDL 270

  Fly   114 VCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILA---NQCGFVGDFLTTYASNLVQF 175
            ||.....:.: ::.|.:|:..|....|.:.||.|| |..::|   .|..|.|  :..:::::..|
  Fly   271 VCGRDILSLV-ETCFLVGAAAGAVLSGWISDRFGR-RHTLMAFVTIQSVFGG--ILAFSTSVAMF 331

  Fly   176 AIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC-FCLGALVAPWLSVLAGNWRIYL 239
            ...|.|.|.|:.....:.|:||:|.::.|.|  .:.|.|.|. ..:..:::..|:.|..:||...
  Fly   332 MSLRVIIGFASMTVTVVSFVLVVELVSGKWR--TVIGILNILPVAISYVLSAGLAYLIRDWRHLQ 394

  Fly   240 TCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRK 304
            ...:...|::...:|.:.||.:||:.:..::.....::..|..||................|.|.
  Fly   395 LAISWPWLIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRA 459

  Fly   305 LSNQPEQTAGIFDLLRTPNLRKVS-------LLVVF------TFMLTSLSFNT-------ISRNV 349
            :.:.||.|..:.......:....|       |||||      |..||.:.:.|       ::.::
  Fly   460 VQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLTLVIWLTLIIIYFGLTLHL 524

  Fly   350 EGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNV 414
            ..:|.:.::..::...|...|..|..|:..:||.:.:....||..||  |.|...|.:     |.
  Fly   525 SNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGL--CCLATNLVS-----NQ 582

  Fly   415 TLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYL 469
            |.::|.|...:..|.....:...:.:...||.||:.|:...:||:..|..:.|:|
  Fly   583 TGVIALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	113/503 (22%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	84/368 (23%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	84/374 (22%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	82/370 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	4.060