Protein Alignment CG14857 and SLC22A10

DIOPT Version :9

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001034841.3
• Gene: SLC22A10 / 387775
• HGNCID: 18057
• Length: 541
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 133/570 - (23%)
• Similarity: 243/570 - (42%)
• Gaps: 95/570 - (16%)

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENR-------- 57
            |.|:::|.:.|..||:|.|.::.:.........|...:|....:|.|.|:...|:|.
Human     1 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGNETG 65

  Fly    58 --SFEEIAAIYAPFG---KEASCTR-------LDKIEGDRVTVS---NETC-QRWIYNYDFGFRS 106
              |.:.:..|..|..   :...|.|       |..:.|...:.|   .|.| ..|:|:..:...:
Human    66 ILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWVYDQSYFPST 130

  Fly   107 MNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVI------LANQCGFVGDFL 165
            :..:.:.||:......:.|.|...|.|:|....|.:.||.|| |.::      ||     :.|..
Human   131 IVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGR-RFILRWCLLQLA-----ITDTC 189

  Fly   166 TTYASNLVQFAIFRCISGLAATANYYLMFIL------VLEYLAPKLRNMAI---SGTLGICFCLG 221
            ..:|.....:.:.|.::|.::      |.|:      :.|::.|..:.:.:   ||.|.|    |
Human   190 AAFAPTFPVYCVLRFLAGFSS------MIIISNNSLPITEWIRPNSKALVVILSSGALSI----G 244

  Fly   222 ALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFV-------VQESAQWLITRTNVEGAIARLKHI 279
            .::...|:.:..:|:       .|.:|.::.:||       :.|||:|||....::..:..|:.:
Human   245 QIILGGLAYVFRDWQ-------TLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKV 302

  Fly   280 AHFNGME--VKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSF 342
            |..||::  .:..:.|..|..  ::.:|.....:|. :.||.|.|::||...::||.....::.|
Human   303 ARTNGIKNAEETLNIEVVRST--MQEELDAAQTKTT-VCDLFRNPSMRKRICILVFLRFANTIPF 364

  Fly   343 NTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALST 407
            .....|::.:|.:.|::..|:..|......:..|..:.:||:.:..|.|...|     |.:..:|
Human   365 YGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVG-----LSILANT 424

  Fly   408 EGAQKNVTLLLAFALPMRLGISMCYTVTSQFAS------ELLPTCVRSRGIAAVHLAAA--GASF 464
            ...::..||.:|.|.   |||. |...|  |:|      ||:||.:|:|. :.:.|.|:  ||:
Human   425 FVPKEMQTLRVALAC---LGIG-CSAAT--FSSVAVHFIELIPTVLRARA-SGIDLTASRIGAA- 481

  Fly   465 VSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADGE 514
            ::|.|:.|.......|.:|..:..:.......:||||.|..||.|:.|.|
Human   482 LAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	127/553 (23%)
		MFS	126..470	CDD:119392	89/375 (24%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	127/553 (23%)
		MFS	143..516	CDD:119392	94/411 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940