DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and CG42269

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	187/594 - (31%)
Similarity:	300/594 - (50%)	Gaps:	48/594 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVP-QHWCYHEALENRSFEEIAA 64
            ||||.||...|..||||.|:.:.:...:|.....|:||..:..:| ||||:...|:....|...|
  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLA 134

  Fly    65 IYAPF--GKEASCTRLD----------KIEGDRVTVSNETCQRWIYNY-DFGFRSMNAELNWVCN 116
            :..|.  |:..:|...|          |:..|......:....|.||: :..:.::..|.||||:
  Fly   135 LSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWVCD 199

  Fly   117 DAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCI 181
            ||......||:||||:::|...||.:.||.||:.|:|..|..|.:....|.:.||..:|||.|..
  Fly   200 DAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFF 264

  Fly   182 SGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQ 246
            .|.|....:.:|:||||||:.||.|....:.::.|.|...|.:.||::....:|:: |.......
  Fly   265 VGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKL-LAIVTSAP 328

  Fly   247 LVVALFY-FVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPE 310
            |::|:|. |||.|||:||:::..|:.|:..||.:...||.:|....::.|..:|   :::..|..
  Fly   329 LLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSC---KRMQEQEA 390

  Fly   311 QTA--GIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFI 373
            |..  .:.||.::|.||:.:||::..:|..||.|:...|||..:||..|..|:|......|:..:
  Fly   391 QNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTL 455

  Fly   374 QGLLQSRVGRKATAFLAMLCTG---LLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVT 435
            ..::..|.||:..|..:|:.:|   ||:..:.|.:.:          .|.|:..|..:::.|.:.
  Fly   456 LTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYS----------AALAIMGRFFVNISYNIG 510

  Fly   436 SQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPE 500
            .|:|:|:|||.||::.:|.:|:....||.::|::::|.....|.|.:||.:|.:......|:|||
  Fly   511 LQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPE 575

  Fly   501 TNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEA----TEEVRLH----------QLNGQ 551
            |.|..||.||:|||.||:|:|:..|.|..:..||...|.    .||||..          .||..
  Fly   576 TLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEVRSQAFVRGTQTGASLNAS 640

  Fly   552 TKSETEAEV 560
            |..|..:.:
  Fly   641 TGGELRSSI 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	159/517 (31%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	110/349 (32%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	146/485 (30%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	111/352 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	7.010