DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and CG8654

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	134/539 - (24%)
Similarity:	213/539 - (39%)	Gaps:	88/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAIYAP 68
            |.|:.:.|...|||.....::....|.|..|......:.......|..|.:.:           |
  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTD-----------P 75

  Fly    69 FGKEASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSL 133
            ...|.|.|..|      .:|...|              :..|.|..|.....|.:.||:..||.|
  Fly    76 CSDECSETEFD------TSVFQST--------------IITEWNLTCESKQLASLSQSIVMLGIL 120

  Fly   134 MGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQ------------FAIFRCISGLAA 186
            .|:..||:..||.||..|            |||.....|:.            :.:||.:..:|.
  Fly   121 FGSILFGMFADRYGRRPA------------FLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVAT 173

  Fly   187 TANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVAL 251
            .......|:|::|.:.||.|.| ::....|.|.:|.......:.....||.:.....:..:|..:
  Fly   174 AGTMTTSFVLLMEIVGPKKREM-VAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVI 237

  Fly   252 FYFVVQESAQWLITRTNVEGAIARLKHIAHFNGM-------EVKAADFEAFRRNCIVKRKLSNQP 309
            :.::|.||.:||.|...::.:|..|:.||..|..       |::|| :.|.         .:.||
  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAA-YGAL---------AARQP 292

  Fly   310 EQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQ 374
            .:...:.||.|||.:|..::.:...:::..:.:...::.|..:|.:.|:..::.|.|..|...:.
  Fly   293 VKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLC 357

  Fly   375 GLLQSRVGRKATAFLAMLCTG----LLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVT 435
            .|:...:|||.|..|:..|:.    ||:|     |||:.....||.    |.....|.|:.:...
  Fly   358 ALMTKYLGRKKTLLLSNGCSALGLILLAC-----LSTQAEAVRVTC----ATIGLFGASITFPNV 413

  Fly   436 SQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGT-KLAAAPSLILALLLLTASGCTLMLP 499
            ..:..||.||.|||.|:....:.....|.|:|.::.|.. .|..|| ||..:..:.|...|:.||
  Fly   414 YLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAP-LIFGIFSILAMLGTIFLP 477

  Fly   500 ETNNRQLPITLADGEAFGK 518
            ||....||.||.|||.||:
  Fly   478 ETRGTPLPETLEDGETFGR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	125/521 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	90/366 (25%)
CG8654	NP_001246441.1	SP	85..487	CDD:273317	112/454 (25%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	105/436 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	4.060