DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	147/583 - (25%)
Similarity:	251/583 - (43%)	Gaps:	83/583 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFE----EIA 63
            |.|::.:.|..||:|..:.:|:|...|.:....:||..:.....|:|....::|.:|.    |..
  Rat     4 FAQVMAEVGDFGRFQVRLTILMGIPNFLSAFFVFSQVFMVLDEAHYCSVSWVKNHTFNLSAAEQL 68

  Fly    64 AIYAP---FGKEASC---------TRLDKIEGDRVTVSNET--CQR-WIYNYDFGFR--SMNAEL 111
            |:..|   .|:..||         ..|:.|...|.   |||  |.. |.|..:   |  |:..|.
  Rat    69 AVSIPNDTAGRPESCLMFRPPPDNASLEDILSHRF---NETQACDSGWDYPEN---RPPSLKNEF 127

  Fly   112 NWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFA 176
            :.||......|..||:|..|.|:|...||.:.|.|||..::::......:....|.:.|:   |.
  Rat   128 DLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLLLSGIASMATAFVSS---FE 189

  Fly   177 IFRCISGLAATANYYLMF---ILVLEYLAPKLRNMAI----SGTLGICFCLGALVAPWLSVLAGN 234
            ::..:....||||...:.   :|:.|::....|..|:    |.     |.||.:....|:....|
  Rat   190 LYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSN-----FALGLMALAGLAYGVRN 249

  Fly   235 WRIYLTCSALLQLV------VALFYF-VVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADF 292
            ||       |||::      :.:||| |:.||.:||:::...|.|...::..|..||..:.:
  Rat   250 WR-------LLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLAS--- 304

  Fly   293 EAFRRNCIVKRKLSNQ--PEQT---AGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGM 352
                       :|.||  ||:|   ....||.|.|.||||:|:::..:.:.||.:..:...|...
  Rat   305 -----------ELLNQLVPEKTGPSGNALDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDF 358

  Fly   353 GLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLL 417
            ||..::...:|.||..|:......:..::|||.:....:...|:: |.:.:.:..:    ..|:.
  Rat   359 GLDIYLTQVIFGVVEVPARLSSIPMMEKLGRKWSQLCTLTLAGVM-CVIIIFIPGD----LPTVA 418

  Fly   418 LAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSL 482
            .|.|:..:...|..:|::..:.:|||||.:|..|:..|.:.:.....::|.::.|.....|.|.|
  Rat   419 TALAVVGKFASSAAFTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPML 483

  Fly   483 ILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRL 545
            |...|.:.|.....:||||..:.|..||.|.|   :|:...|:....:..|..:...|...|:
  Rat   484 IFGSLPIGAGLLCALLPETRGQTLKDTLQDLE---QGQPPRSYKTAPQRKDVEASGRTSSARV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	136/537 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	89/362 (25%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	136/537 (25%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	97/394 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950