DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	145/600 - (24%)
Similarity:	244/600 - (40%)	Gaps:	87/600 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEAL----ENRSFEE-- 61
            |..:|...|..|.:|:.::.|....:..:|....|.:.:....:.:|....:    .|.:.:|
  Rat    51 FASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHFLLTAQRPYCNTSWILQVGPNLTEDEQL 115

  Fly    62 -IAAIYAPFGKEASCTRLDKIEGDRVTVSN------ETCQR-WIYNYDFGFRSMNAELNWVCNDA 118
             :....||.|...:|.....:..|..::.:      |||:. |||.:.. .||:..|.:.||.:.
  Rat   116 NLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTETCKHGWIYPFAH-TRSLTNEFDLVCGNE 179

  Fly   119 YKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISG 183
            .....||::|..|.|.|:..||.|.|::||...::|:.....:..|.|.:.::..|:..||....
  Rat   180 PHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVNSFYQYLFFRFFVA 244

  Fly   184 LAATANYYLMFILVLEYLAPKLRNMAISGTLGIC-FCLGALVAPWLSVLAGNWRIYLTCSALLQL 247
            .|:.........||:|:|..:.|..||  .|..| |.:|.::....:....:||:......:...
  Rat   245 QASVGYAICSVSLVMEWLVGEHRAQAI--ILQHCFFTIGVILLTGFAYKINHWRLLFLLGGVPMF 307

  Fly   248 VVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQT 312
            .:....:|:|||.:||:.:..||.|...|.:.|..|...:..        |.:.:.:|..: :..
  Rat   308 PLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIPL--------NLLNELQLPGK-KAK 363

  Fly   313 AGIFDLLRTPNLRKVSL---LVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQ 374
            |.|.|.....:|.||.|   .|.||....||   |:|..::..||..:.:..:..:...|:....
  Rat   364 ASILDFYTNQHLFKVVLAMGCVWFTVSYVSL---TLSLKMKDFGLDIYFIQVVPCITAVPARLCC 425

  Fly   375 GLLQSRVGRK-----ATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLG-ISMCYT 433
            .||....|||     ..:.:...|..|        |......|:.|:|:     :.|| .||..|
  Rat   426 ILLLEYFGRKWSLNLTLSLVTFTCLSL--------LFVPEELKSTTILM-----LVLGEFSMAGT 477

  Fly   434 VTSQF--ASELLPTCVRSRGIAAVHLA-AAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCT 495
            |:..|  .:|||||.:||.|:..|.:| .|||  :|...|...|| ...|.....|..:.|...:
  Rat   478 VSIFFIYTAELLPTILRSTGLGMVSIAWTAGA--ISSLAIFKQTK-TQLPIFFCCLCCILALCFS 539

  Fly   496 LMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQ------------- 547
            .::|||.|:    .|.|...:...:|:       .|.|. ||::::.:...:
  Rat   540 SLVPETGNQ----PLRDSIEYCSRDSL-------EHKDK-SKDSSKVLMAEESMCDVAADSVLTK 592

  Fly   548 ---LNGQT-KSETEA 558
               .|..| ||||::
  Rat   593 NTMFNAMTLKSETDS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	130/524 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	93/356 (26%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	110/410 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100