DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	574	Identity:	142/574 - (24%)
Similarity:	254/574 - (44%)	Gaps:	60/574 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQH-------------WCYHE- 52
            |:|:::...|..|.:|.|:..||.........:..|...:...|:|             |..|.
Mouse     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSI 67

  Fly    53 ALENRSFEEI-----------AAIYAPFGKE-ASCTRLDKIEGDRVTVSNETC-QRWIYNYDFGF 104
            .||.:...::           .|.::..|.| .....|:::|       .|:| ..|.|:.|...
Mouse    68 PLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLE-------QESCLDGWEYDKDIFL 125

  Fly   105 RSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVI--LANQCGFVGDFLTT 167
            .::..|.|.||.|.:|..:..||||:|.|.|:|..|.|.||.||.:.:.  :|.|.||  .|:..
Mouse   126 STIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGF--SFVQI 188

  Fly   168 YASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC--FCLGALVAPWLSV 230
            :::|...|.:...|.|:...:||.:.|||..|.|:..:|  .|..|||:|  |.:|.:|.|..:.
Mouse   189 FSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVR--IIFSTLGVCTFFAIGYMVLPLFAY 251

  Fly   231 LAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAF 295
            ...:||:.|....|..|.....::.:.||.:|||::.....|...::..|..|.:...|..|:.
Mouse   252 FIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDP- 315

  Fly   296 RRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVF 360
                :..::|::..:|...|.||.||.|:..::::.|..:||||:.:..:|.||..:....::..
Mouse   316 ----LELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNC 376

  Fly   361 SLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLL-LAFALPM 424
            .|..::..|:.|...||...:.|:      .:..|:|....||.|..:...::...: :...:..
Mouse   377 FLSGLIEVPAYFTAWLLLRTLPRR------YIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLG 435

  Fly   425 RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLL 489
            :.||:..:::...|.:||.||.||:..:....:|:...|.::||.::||......|.:::..|.:
Mouse   436 KFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTV 500

  Fly   490 TASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEV 543
            .....||..||:....||      |...:.:.:..|.|.::....|.:|.:.:|
Mouse   501 LIGIITLFFPESFGVTLP------ENLEQMQKVRGFRCGKKSTVSVDREESPKV 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	134/529 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	95/348 (27%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	134/534 (25%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	107/401 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950