DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	146/593 - (24%)
Similarity:	256/593 - (43%)	Gaps:	88/593 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC-------YHEALENRSF 59
            |:|::....|..|.:|.|:..||.........:..|...:...|:|.|       ...|..|.|.
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    60 EEIAAIYAPFGKEA--SCTR---------------------LDKIEGDRVTVSNETC-QRWIYNY 100
                .:....|::.  ||.|                     |:::|       .|.| ..|.||.
  Rat    68 ----PLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLE-------QENCLDGWEYNK 121

  Fly   101 DFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL--ANQCGFVGD 163
            |....::..|.:.||.|.:||.:..||||:|.|||:|..|.|.||.||...:.|  ..|.||  .
  Rat   122 DVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGF--S 184

  Fly   164 FLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC--FCLGALVAP 226
            ||..::.|...|.:...:.|:...:||...|:|..|.|:..:|  .|..|||:|  :..|.:|.|
  Rat   185 FLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIR--IIFATLGVCIFYAFGFMVLP 247

  Fly   227 WLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAAD 291
            ..:....:||:.|....:..::....::.:.||.:|||::..|:.|...::..|.|||:...:..
  Rat   248 LFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTI 312

  Fly   292 FEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSP 356
            |:...     .:.|:::..|:..|:||:||.|:|.::::.:..::..|:.:..:|.:...:....
  Rat   313 FDPSE-----LQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDI 372

  Fly   357 FVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFA 421
            :|...|.|.|..|:..:..||...:.|:.:...|:...|  |..|.:.|     ..:....|:.|
  Rat   373 YVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGG--SVLLFIQL-----VPSELFYLSTA 430

  Fly   422 LPM--RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLIL 484
            |.|  :.||:..|::...:.:||.||.||:.|:.....|:...|.:|||.::||......|.:::
  Rat   431 LVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILM 495

  Fly   485 ALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQLN 549
            ..|.:..:..||..||:....||.|:         :.||               ..:.::..|:.
  Rat   496 GSLTILTAILTLFFPESFGAPLPDTI---------DQML---------------RVKGIKQWQIQ 536

  Fly   550 GQTKSETE 557
            .||:::.:
  Rat   537 SQTRTQKD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	138/534 (26%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	97/349 (28%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	138/534 (26%)
		MFS	123..510	CDD:119392	109/402 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950