DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	137/547 - (25%)
Similarity:	244/547 - (44%)	Gaps:	48/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAI 65
            |.|:.:|::.|..||:|.:.:.::.........|...||....:|.|.|...|..|.|.:.....
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    66 YAPFGKEA---SCTRL------------DKIEGDRVTVSNETC-QRWIYNYDFGFRSMNAELNWV 114
            :.|..|:.   ||.|.            .:..|.|||   |.| ..|:|:......::..|.|.|
  Rat    66 WLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVT---EPCIDGWVYDNSTFPSTIVTEWNLV 127

  Fly   115 CNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFR 179
            |:.....::.|||:.:|.|:|...||.|.||:||.:.:||......|......||.|...:.:||
  Rat   128 CSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFR 192

  Fly   180 CISGLAATANYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTCSA 243
            .:||::..:.......|.:|::  .:...|..||| |..:.||..:...::....:||
  Rat   193 LLSGMSLASIAINCMTLNVEWM--PIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWR------- 248

  Fly   244 LLQLVVALFYFVV-------QESAQWLITRTNVEGAIARLKHIAHFNGMEVKAA--DFEAFRRNC 299
            .|||||::.:|:.       .|||:|..:...::..:..|:.:|..||.:.:.|  ..|..|.:
  Rat   249 HLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTS- 312

  Fly   300 IVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFA 364
             ::::|:....| |...:|||.|.||.:.|.:...:..||.::..:..:::|.|:|.:::..:|.
  Rat   313 -LQKELTLSKGQ-ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFG 375

  Fly   365 VVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLG-I 428
            .|..|:.|:..|:.:.:||:.....::|..|:.....|:      ..|:.|::......:..| :
  Rat   376 AVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGI------IPKSHTIIRTSLAVLGKGCL 434

  Fly   429 SMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASG 493
            :..:.....:..||.||.:|..|:......|...|.|||.:........:.|..|...:.:.||.
  Rat   435 ASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASA 499

  Fly   494 CTLMLPETNNRQLPITLADGEAFGKGE 520
            .|.:||||..:.||.|:.|.::..:|:
  Rat   500 VTALLPETLGQPLPDTVQDLKSRSRGK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	131/524 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	89/354 (25%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	131/524 (25%)
		MFS	135..505	CDD:119392	95/387 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950