DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	149/580 - (25%)
Similarity:	249/580 - (42%)	Gaps:	82/580 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQ-HWC---YHEALENR---SFE 60
            |||.|.|.|..||:|..:.|||.....|....:.....:|..|. :||   ...||..|   |.|
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    61 E-----IAAIYAPFGK--EASCTRLDKIEGDRVTVSNETCQ-------------------RWIYN 99
            |     ...::.|..:  :..|.|.  :..|..|.|..:|.                   |::..
  Rat    69 EEWNLTTPELHVPAERRGQGHCHRY--LLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVET 131

  Fly   100 YDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVG-- 162
            :.    ::.::.:.||.:|:...:.|::..||.|.|.||.|...||.||:  ::....|..||
  Rat   132 HS----TIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL--IVYLISCFGVGIT 190

  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPW 227
            ..:..:|.|...|.|||.:.|:.....:...|::|.|.:..|.|.: :...:.:.|.||.::.|.
  Rat   191 GVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRI-VGIVIQMFFTLGIIILPG 254

  Fly   228 LSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNG-------M 285
            ::....:|:......:|...:..|:|:||.||.:|||||...|.|:..|:.:|..||       .
  Rat   255 IAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYS 319

  Fly   286 EVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVE 350
            |:...|.|....:|:                ||:|||.:||.:|:::|.:..:::.:..:...:.
  Rat   320 EITVTDEEVSNPSCL----------------DLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLG 368

  Fly   351 GMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVT 415
            .:|.:.::.|.:..:|..|...:..|...|:||:.....:.:..| :|| |..|...||..   .
  Rat   369 LIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAG-VSC-LVTAFLPEGIP---W 428

  Fly   416 LLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAA-- 478
            |....|...||||:|.:.:.....|||.||.:|:.|::...........::|:|:.   :|||
  Rat   429 LRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF---RLAAIW 490

  Fly   479 --APSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVS 536
              .|.:|..:|.....|..::||||....||.|:.|.|..|..:   ...|.|:....||
  Rat   491 LELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQ---LHQCGRKKKTQVS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	136/543 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	92/352 (26%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	136/543 (25%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	102/394 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950