Protein Alignment CG14857 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_062103.1
• Gene: Slc22a3 / 29504
• RGDID: 3701
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 149/580 - (25%)
• Similarity: 249/580 - (42%)
• Gaps: 82/580 - (14%)

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQ-HWC---YHEALENR---SFE 60
            |||.|.|.|..||:|..:.|||.....|....:.....:|..|. :||   ...||..|   |.|
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    61 E-----IAAIYAPFGK--EASCTRLDKIEGDRVTVSNETCQ-------------------RWIYN 99
            |     ...::.|..:  :..|.|.  :..|..|.|..:|.                   |::..
  Rat    69 EEWNLTTPELHVPAERRGQGHCHRY--LLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVET 131

  Fly   100 YDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVG-- 162
            :.    ::.::.:.||.:|:...:.|::..||.|.|.||.|...||.||:  ::....|..||
  Rat   132 HS----TIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL--IVYLISCFGVGIT 190

  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPW 227
            ..:..:|.|...|.|||.:.|:.....:...|::|.|.:..|.|.: :...:.:.|.||.::.|.
  Rat   191 GVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRI-VGIVIQMFFTLGIIILPG 254

  Fly   228 LSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNG-------M 285
            ::....:|:......:|...:..|:|:||.||.:|||||...|.|:..|:.:|..||       .
  Rat   255 IAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYS 319

  Fly   286 EVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVE 350
            |:...|.|....:|:                ||:|||.:||.:|:::|.:..:::.:..:...:.
  Rat   320 EITVTDEEVSNPSCL----------------DLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLG 368

  Fly   351 GMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVT 415
            .:|.:.::.|.:..:|..|...:..|...|:||:.....:.:..| :|| |..|...||..   .
  Rat   369 LIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAG-VSC-LVTAFLPEGIP---W 428

  Fly   416 LLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAA-- 478
            |....|...||||:|.:.:.....|||.||.:|:.|::...........::|:|:.   :|||
  Rat   429 LRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF---RLAAIW 490

  Fly   479 --APSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVS 536
              .|.:|..:|.....|..::||||....||.|:.|.|..|..:   ...|.|:....||
  Rat   491 LELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQ---LHQCGRKKKTQVS 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	136/543 (25%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	136/543 (25%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		2/3 (67%)