DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	147/582 - (25%)
Similarity:	245/582 - (42%)	Gaps:	53/582 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQ--YLMILLL--GYIAFTTTVHYYSQNIIGFVPQHWCYH-----EALEN 56
            |.|..:|:..|..||:|  |..:|||  |.:|    .|.:.||.....|.|.|.|     ||..|
  Rat     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLA----CHTFLQNFTAAAPPHHCQHPANYTEATTN 61

  Fly    57 RSFEEIAAIYA--PFGKEASCTRLDK-----IEGDRVT--VSNETCQ-RWIYNYDFGFRSMNAEL 111
            .|...:.|...  ..|....|.|..:     :|.:..:  |:.|.|: .|:|:......::..|.
  Rat    62 DSGAWLRATIPLNQHGVPEPCQRYTEPQWALLEPNTSSHGVATEGCKDGWVYDRSIFPSTIVMEW 126

  Fly   112 NWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFA 176
            :.||.......:.||::..|.|:|...||.|.||:||...::.:.....|...:|.|..:...:.
  Rat   127 DLVCEARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPLVWSYLQLAVSGAVTAYVGSFSAYC 191

  Fly   177 IFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWR-IYLT 240
            |||.:.|:..:........||:|::..:.|.:| ...||..|.||.|:...::.|...|| :...
  Rat   192 IFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPWRWLQFA 255

  Fly   241 CSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADF-----EAFRRNCI 300
            .||.. ||..|:.:.:.||::||:.....:.|:..|:.:|..||.:.:....     .::.:|..
  Rat   256 VSAPF-LVFFLYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRKAEGERLTIEVVSSYIQNEF 319

  Fly   301 VKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAV 365
            ...:.||      .|.||.|||.:|||:..::..:...|:::..::.:::..|||.::|.:||.:
  Rat   320 ASVRTSN------SILDLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGI 378

  Fly   366 VVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISM 430
            :..|:..:.......|||:||....::..||:  .:......|..|...|:..|..........:
  Rat   379 IDIPAMLVATTTMIYVGRRATVSSFLVLAGLM--VIANMFVPEDLQTLRTVQAALGKGCLASSFI 441

  Fly   431 CYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLIL-ALLLLTASGC 494
            |..:   |..||.||.:|..|:....:.|......:|.:..||......|.:.. |..:|.....
  Rat   442 CVYL---FTGELYPTEIRQMGMGFASVNARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMAV 503

  Fly   495 TLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQLNGQTKSET 556
            ...|.||.|..|..|:|..|:..|          ..|....:::..||:.|.||......||
  Rat   504 ICFLTETRNVPLVETIAAMESRVK----------EGHSKRDTEQKNEEISLQQLGAPPLKET 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	132/523 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	87/349 (25%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	100/417 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940