Protein Alignment CG14857 and SLC22A24

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001129978.2
• Gene: SLC22A24 / 283238
• HGNCID: 28542
• Length: 552
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 149/567 - (26%)
• Similarity: 245/567 - (43%)
• Gaps: 89/567 - (15%)

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYS---QNIIGFVPQHWCYHEALEN------ 56
            |.||.:|::.|..||:|   |.|:.:...|..:.:.:   :|...|.|.|.|:...|:|
Human     1 MGFDVLLDQVGGMGRFQ---ICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62

  Fly    57 ----RSFEEIAAIYAPFG---KEASCTR-------LDKIEGDRVTVSN------ETC-QRWIYNY 100
                .|.:::..|..|..   :...|.|       |..:.|   |..|      |.| ..|:|:.
Human    63 DTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNG---TFPNTNEPDTEPCVDGWVYDR 124

  Fly   101 DFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGF---VG 162
            .....::..|.:.||.......:.||||..|||:|...:|.|.||:||   .|:...|..   :.
Human   125 SSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGR---KIICKLCFLQLAIS 186

  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC-FCLGALVAP 226
            :....:|...:.:.|.|.::|.:........|||.||:..|:.|:|.|...|  | :.:|.::..
Human   187 NTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLL--CSYSVGQMLLG 249

  Fly   227 WLSVLAGNWRI-YLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAA 290
            .|:....:|.| .||.|..: :|:.|..:.:.|||:|||....::..:..|:.:||.||.:....
Human   250 GLAFAIQDWHILQLTVSTPI-IVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEE 313

  Fly   291 DFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLS 355
            ..........:|::|.....:|: ||.|.|.|.||.....:.|.....::.|..:..|::.:|.:
Human   314 TLTTELVRSTMKKELDAVRIKTS-IFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSN 377

  Fly   356 PFVVFSLFAVVVPPSGF----IQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTL 416
                .|||.::.....|    :..|..:.:||:.:..|.....||.     :.::|...|:...|
Human   378 ----VSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF-----ILVNTFLPQEMQIL 433

  Fly   417 LLAFALPMRLGI---SMCYTVTSQFASELLPTCVRS--RGIAAVHLAAAGASFVSPYLIHLGTKL 476
            .:..|   .|||   |......|...:||:||.:||  .||.||. ...||: ::|.|:   |.:
Human   434 RVVLA---TLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVS-GRTGAA-LAPLLM---TLM 490

  Fly   477 AAAPSL---------ILALLLLTASGCTLMLPETNNRQLPITLADGE 514
            |.:|.|         |||:.::      |:||||.:..||.|:.|.|
Human   491 AYSPHLPWISYGVFPILAVPVI------LLLPETRDLPLPNTIQDVE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	142/550 (26%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	113/436 (26%)