DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	145/554 - (26%)
Similarity:	246/554 - (44%)	Gaps:	57/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRS-------FEE 61
            |.:||:.|..|.:|....|||..|:.:....|.....:||.|.|:|.:..:...|       .||
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEE 69

  Fly    62 IAAIYAPFG--KEAS----CTR---------LDKIEGDRVTVSNET------CQR-WIYNYDFGF 104
            :.......|  .|||    |.|         ||.::.....|:|.:      |:. |:  ||...
  Rat    70 LNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWV--YDTPG 132

  Fly   105 RSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYA 169
            .|:..|.|.||.||:|..:.||...||..:|:...|.:.||.||...:::......|...||..|
  Rat   133 SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVA 197

  Fly   170 SNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAG- 233
            .:.....:||.:.|:.:..::...:.|:.|::....|.     |..|.:.:...|.  |..|||
  Rat   198 PDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRR-----TTAILYQMAFTVG--LVGLAGV 255

  Fly   234 -----NWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFE 293
                 :||......:|...:..|:|:.|.||.:||:::.....|:..::.||..|| :|..||.:
  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNG-KVPPADLK 319

  Fly   294 AFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFV 358
            ..   |:.:   ....:::....||.|||||||.::::::.:...::.:..:..:|...|.:.::
  Rat   320 ML---CLEE---DASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYL 378

  Fly   359 VFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALP 423
            .|...::|..|:.||..:...|:||......:.|.|| .:|.|.:.:..|....||||    |..
  Rat   379 DFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTG-AACLLMIFIPHELHWLNVTL----ACL 438

  Fly   424 MRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLI-HLGTKLAAAPSLILALL 487
            .|:|.::...:.....:||.||.:|:.|:.............:|::: .|.....|.|.::..:|
  Rat   439 GRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVL 503

  Fly   488 LLTASGCTLMLPETNNRQLPITLADGEAFGKGES 521
            .|||...||:||||....||.|:.:.|..|:.:|
  Rat   504 GLTAGAMTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	138/533 (26%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	84/349 (24%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	138/533 (26%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	105/410 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950