Protein Alignment CG14857 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 145/554 - (26%)
• Similarity: 246/554 - (44%)
• Gaps: 57/554 - (10%)

  Fly     4 DQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRS-------FEE 61
            |.:||:.|..|.:|....|||..|:.:....|.....:||.|.|:|.:..:...|       .||
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEE 69

  Fly    62 IAAIYAPFG--KEAS----CTR---------LDKIEGDRVTVSNET------CQR-WIYNYDFGF 104
            :.......|  .|||    |.|         ||.::.....|:|.:      |:. |:  ||...
  Rat    70 LNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWV--YDTPG 132

  Fly   105 RSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYA 169
            .|:..|.|.||.||:|..:.||...||..:|:...|.:.||.||...:::......|...||..|
  Rat   133 SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVA 197

  Fly   170 SNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAG- 233
            .:.....:||.:.|:.:..::...:.|:.|::....|.     |..|.:.:...|.  |..|||
  Rat   198 PDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRR-----TTAILYQMAFTVG--LVGLAGV 255

  Fly   234 -----NWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFE 293
                 :||......:|...:..|:|:.|.||.:||:::.....|:..::.||..|| :|..||.:
  Rat   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNG-KVPPADLK 319

  Fly   294 AFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFV 358
            ..   |:.:   ....:::....||.|||||||.::::::.:...::.:..:..:|...|.:.::
  Rat   320 ML---CLEE---DASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYL 378

  Fly   359 VFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALP 423
            .|...::|..|:.||..:...|:||......:.|.|| .:|.|.:.:..|....||||    |..
  Rat   379 DFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTG-AACLLMIFIPHELHWLNVTL----ACL 438

  Fly   424 MRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLI-HLGTKLAAAPSLILALL 487
            .|:|.::...:.....:||.||.:|:.|:.............:|::: .|.....|.|.::..:|
  Rat   439 GRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVL 503

  Fly   488 LLTASGCTLMLPETNNRQLPITLADGEAFGKGES 521
            .|||...||:||||....||.|:.:.|..|:.:|
  Rat   504 GLTAGAMTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	138/533 (26%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	138/533 (26%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		2/3 (67%)