DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	571	Identity:	139/571 - (24%)
Similarity:	231/571 - (40%)	Gaps:	102/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALEN--------- 56
            |.|.::|.:.||.||:|.|.|:.|..:......|...:|....:|.|.|:...|:|
Mouse     1 MSFQELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPILDNDTASDNGSR 65

  Fly    57 -RSFEEIAAIYAPFGKEASCTRLDK-------------IEGDRVTVS---NETC-QRWIYNYDFG 103
             .|.:::..|..|..   |..||||             :.|....||   .|.| ..|:|:....
Mouse    66 ILSQDDLLRISIPLD---SNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNF 127

  Fly   104 FRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTY 168
            ..::..|.:.||.......:.:..|.:|..:|....|.|.||.||              .|:.|.
Mouse   128 LSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGR--------------KFILTC 178

  Fly   169 ASNLVQFAI----------------FRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC 217
            |  |:||||                .|.::|::.........:|:||:.:||.  :|:...|..|
Mouse   179 A--LLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKF--LAMMAVLSSC 239

  Fly   218 F-CLGALVAPWLSVLAGNW-RIYLTCSALLQLVVALFYFVV-----QESAQWLITRTNVEGAIAR 275
            . .:|.::...|:.|...| .:.||.||      .:|:|::     .|||:|||.....:..:..
Mouse   240 APNIGFMILAGLAFLFRIWHHLQLTMSA------PIFFFLILTRWLSESARWLILINKPQKGLKE 298

  Fly   276 LKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQT---AGIFDLLRTPNLRKVSLLVVFTFML 337
            |:.:||.|||: .:.|....    ||:..:..:.|..   ..:.||..|..|||  .:.|.:|:.
Mouse   299 LRKVAHMNGMK-NSGDLTME----IVRTSMKAELEAAKTKPSLRDLFHTSILRK--RICVLSFIR 356

  Fly   338 TSLSFNTISRNVEGMGLSPFVV-----FSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLL 397
            ...:.:.|...|....||..::     .|..|::|   ..|...:.:.:||:.|..:.|...|:.
Mouse   357 LFFTVSIIGLAVHLQHLSSNIILLQFLISALAILV---SVIGPFVLNHIGRRITYLVLMSLRGIF 418

  Fly   398 SCALGVALSTEGAQKNVTLLLAFALPMRLGI-SMCYTVTSQFASELLPTCVRSRGIAAVHLAAAG 461
                 :.::....|:..||.:..| .:..|| |:|..|:....:|||||.:|:..:..:......
Mouse   419 -----IMIAVFVPQEMQTLRIIMA-TLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNS 477

  Fly   462 ASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLAD 512
            ..|:||..:.:.|..|..|.:......:..:....:||||.|:.||.:..|
Mouse   478 GLFLSPLFMLVATYYANLPWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	135/556 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	92/375 (25%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	103/445 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940