DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	590	Identity:	147/590 - (24%)
Similarity:	246/590 - (41%)	Gaps:	87/590 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALEN--------- 56
            |.|..:|...||.||:|.|.:..|......|..|...:|.......|.|:...::|
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSG 65

  Fly    57 -RSFEEIAAIYAPFG---KEASCTR-------LDKIEGDRVTVSN------ETC-QRWIYNYDFG 103
             .|.:::..|..|..   :...|.|       |.:..|   :.||      |.| ..|:|:....
Mouse    66 ILSQDDLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNG---SFSNMTEPDTEPCMDGWVYDQRTF 127

  Fly   104 FRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGR---VRAVILANQCGFVGDFL 165
            ..:...|.|.||.......:.:.:|.:|.|.|.|..|.|.|:.||   .|..:|  |....|. .
Mouse   128 LSTTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALL--QMAITGT-C 189

  Fly   166 TTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGI-CFCLGALVAPWLS 229
            |..|.....:.:.|.::||..........:|:||:.:||  ..|:..||.: ....|.|:...|:
Mouse   190 TALAPTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPK--TQALVTTLSMSSHHFGGLILAGLA 252

  Fly   230 VLAGNWRIYLTCSALLQLVVALFYFV--------VQESAQWLITRTNVEGAIARLKHIAHFNGME 286
            ....||.       .|||.:::..||        :.|||:|||.....:.|:..|:.:|..||::
Mouse   253 FAFQNWH-------HLQLAISVPIFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIK 310

  Fly   287 VKAAD---FEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRK-VSLLVVFTFMLTSLSFNTISR 347
             .:.|   .|..|  .|:|.::: .|.....:.||...||||| :.||.:..|:..|.:.. |:.
Mouse   311 -NSEDVLTMEVVR--TIMKDEIA-IPRTKPSLRDLFHMPNLRKRLCLLCLLRFLQISPTVG-INM 370

  Fly   348 NVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQK 412
            |::.:..:.|:..||.:....|:..:.|.|.:.:||:.:..|..|..|:.      .||.....:
Mouse   371 NLQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIF------LLSIVSVPQ 429

  Fly   413 NVTLLLAFALPMRLGIS-MCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKL 476
            .:..||...:.:..|.| |.|.....::|||:||.:|:..:..:.:.....:.:||.::.|....
Mouse   430 EMQTLLVVLITLAGGSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYS 494

  Fly   477 AAAPSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDC-W----RRHDDDVS 536
            |:.|.:|..:|.:......|:||||.|:.||.::.|.|            | |    ::.::||.
Mouse   495 ASLPWIIYGVLSILGGLLPLILPETKNQPLPDSIQDVE------------CGWESSKQKKEEDVI 547

  Fly   537 KEATE 541
            .:.|:
Mouse   548 IKVTQ 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	137/541 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	94/360 (26%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	106/419 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030