DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	594	Identity:	141/594 - (23%)
Similarity:	254/594 - (42%)	Gaps:	86/594 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQH-------------WCYHE- 52
            |:|::....|..|.:|.|:..||.........:..|...:...|:|             |..|.
Mouse     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    53 ALENRSFEEI--------AAIYAPF-------GKEASCTRLDKIEGDRVTVSNETC-QRWIYNYD 101
            .||.:...::        .|..|.|       |::....:|::          |:| ..|.|:.|
Mouse    68 PLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQ----------ESCLDGWEYDKD 122

  Fly   102 FGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL--ANQCGFVGDF 164
            ....::..|.:.||.|.:||.:..||||:|.|||:|..|.|.||.||...:.|  ..|.||  .|
Mouse   123 VFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGF--SF 185

  Fly   165 LTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGIC--FCLGALVAPW 227
            |..::.|...|.:...:.|:...:||...|:|..|.|:..:|  .|..|||:|  :..|.:|.|.
Mouse   186 LQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIR--IIFATLGVCIFYAFGFMVLPL 248

  Fly   228 LSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADF 292
            .:....:||:.|....:..::....::.:.||.:|||::..::.|...::..|..||:...:..|
Mouse   249 FAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIF 313

  Fly   293 EAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPF 357
            :...     .:.|::...|...|:||:||.|:|.::::.:..::..|:.:..:|.:...:....:
Mouse   314 DPSE-----LQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIY 373

  Fly   358 VVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFAL 422
            |...|.|.|..|:..:..||...:.|:.:...|:...|.:...:.:..|.       ...|:.||
Mouse   374 VNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSE-------LFYLSTAL 431

  Fly   423 PM--RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILA 485
            .|  :.||:..|::...:.:||.||.||:.|:.....|:...|.:|||.::||......|.:::.
Mouse   432 VMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMG 496

  Fly   486 LLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQLNG 550
            .|.:..:..||..||:....||.|:         :.||               ..:.::..|:..
Mouse   497 SLTILTAILTLFFPESFGVPLPDTI---------DQML---------------RVKGIKQWQIQS 537

  Fly   551 QTKSETEAE 559
            ||:.:.:.|
Mouse   538 QTRMQKDGE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	132/533 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	93/349 (27%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	132/533 (25%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	105/402 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950